7TZ7
PI3K alpha in complex with an inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | polymer | 1074 | 125287.8 | 1 | UniProt (P42336) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (human) | PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,p110alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA |
2 | B | Isoform 3 of Phosphatidylinositol 3-kinase regulatory subunit alpha | polymer | 291 | 34884.4 | 1 | UniProt (P27986) Pfam (PF00017) Pfam (PF16454) In PDB | Homo sapiens (human) | PI3-kinase regulatory subunit alpha,PI3K regulatory subunit alpha,PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PI3-kinase subunit p85-alpha,PtdIns-3-kinase regulatory subunit p85-alpha |
3 | A | (4S,5R)-3-[2'-amino-2-(morpholin-4-yl)-4'-(trifluoromethyl)[4,5'-bipyrimidin]-6-yl]-4-(hydroxymethyl)-5-methyl-1,3-oxazolidin-2-one | non-polymer | 455.4 | 1 | Chemie (KVJ) | |||
4 | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A: 1 - 1068 (UniProt: P42336)
B: 301 - 591 (UniProt: P27986)
PDB | External Database | Details |
---|---|---|
Lys 232 | Met 232 | engineered mutation |
Lys 233 | Leu 233 | engineered mutation |
His 1069 | - | expression tag |
His 1070 | - | expression tag |
His 1071 | - | expression tag |
His 1072 | - | expression tag |
His 1073 | - | expression tag |
His 1074 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Tyr 306 | Thr 6 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 160172.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 455.4 | |
All* | Total formula weight | 160627.6 |