7TYW
Human Amylin1 Receptor in complex with Gs and salmon calcitonin peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | E | Receptor activity-modifying protein 1 | polymer | 149 | 17066.7 | 1 | UniProt (O60894) Pfam (PF04901) In PDB | Homo sapiens (human) | Calcitonin-receptor-like receptor activity-modifying protein 1,CRLR activity-modifying protein 1 |
2 | P | Calcitonin-1 | polymer | 33 | 3436.9 | 1 | UniProt (B5XGR7) In PDB | Salmo salar | Calcitonin-1 precursor,calcitonin-1-like isoform X1 |
3 | R | Calcitonin receptor | polymer | 501 | 58469.6 | 1 | UniProt (P30988) Pfam (PF02793) Pfam (PF00002) In PDB | Homo sapiens (human) | CT-R |
4 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45699.4 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
5 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38534.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
6 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
7 | N | nanobody 35 | polymer | 138 | 15140.7 | 1 | Lama glama (Llama) | ||
8 | E, R | PALMITIC ACID | non-polymer | 256.4 | 2 | Chemie (PLM) | |||
9 | R | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
10 | R | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 2 | Chemie (Y01) | |||
11 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
E: 27 - 148 (UniProt: O60894)
P: 1 - 32 (UniProt: B5XGR7)
R: 25 - 474 (UniProt: P30988)
A: 1 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Met 0 | - | expression tag |
Lys 1 | - | expression tag |
Thr 2 | - | expression tag |
Ile 3 | - | expression tag |
Ile 4 | - | expression tag |
Ala 5 | - | expression tag |
Leu 6 | - | expression tag |
Ser 7 | - | expression tag |
Tyr 8 | - | expression tag |
Ile 9 | - | expression tag |
Phe 10 | - | expression tag |
Cys 11 | - | expression tag |
Leu 12 | - | expression tag |
Val 13 | - | expression tag |
Phe 14 | - | expression tag |
Ala 15 | - | expression tag |
Asp 16 | - | expression tag |
Tyr 17 | - | expression tag |
Lys 18 | - | expression tag |
Asp 19 | - | expression tag |
Asp 20 | - | expression tag |
Asp 21 | - | expression tag |
Asp 22 | - | expression tag |
Lys 23 | - | expression tag |
His 24 | - | expression tag |
Gly 25 | - | expression tag |
Ser 26 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Nh2 33 | - | amidation |
PDB | External Database | Details |
---|---|---|
Met -7 | - | expression tag |
Lys -6 | - | expression tag |
Thr -5 | - | expression tag |
Ile -4 | - | expression tag |
Ile -3 | - | expression tag |
Ala -2 | - | expression tag |
Leu -1 | - | expression tag |
Ser 0 | - | expression tag |
Tyr 1 | - | expression tag |
Ile 2 | - | expression tag |
Phe 3 | - | expression tag |
Cys 4 | - | expression tag |
Leu 5 | - | expression tag |
Val 6 | - | expression tag |
Phe 7 | - | expression tag |
Ala 8 | - | expression tag |
Asp 9 | - | expression tag |
Tyr 10 | - | expression tag |
Lys 11 | - | expression tag |
Asp 12 | - | expression tag |
Asp 13 | - | expression tag |
Asp 14 | - | expression tag |
Asp 15 | - | expression tag |
Leu 16 | - | expression tag |
Glu 17 | - | expression tag |
Val 18 | - | expression tag |
Leu 19 | - | expression tag |
Phe 20 | - | expression tag |
Gln 21 | - | expression tag |
Gly 22 | - | expression tag |
Pro 23 | - | expression tag |
Ala 24 | - | expression tag |
Leu 447 | Pro 447 | conflict |
Pro 475 | - | expression tag |
Ala 476 | - | expression tag |
Gly 477 | - | expression tag |
Leu 478 | - | expression tag |
Glu 479 | - | expression tag |
Val 480 | - | expression tag |
Leu 481 | - | expression tag |
Phe 482 | - | expression tag |
Gln 483 | - | expression tag |
Gly 484 | - | expression tag |
Pro 485 | - | expression tag |
His 486 | - | expression tag |
His 487 | - | expression tag |
His 488 | - | expression tag |
His 489 | - | expression tag |
His 490 | - | expression tag |
His 491 | - | expression tag |
His 492 | - | expression tag |
His 493 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asn 54 | Ser 54 | conflict |
Ala 226 | Gly 226 | conflict |
Ala 268 | Glu 268 | conflict |
Lys 271 | Asn 271 | conflict |
Asp 274 | Lys 274 | conflict |
Lys 280 | Arg 280 | conflict |
Asp 284 | Thr 284 | conflict |
Thr 285 | Ile 285 | conflict |
Ser 366 | Ala 366 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 7 |
Total formula weight | 186208.6 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1928.7 | |
All* | Total formula weight | 188137.3 |