7TYO
Calcitonin receptor in complex with Gs and human calcitonin peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45699.4 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38534.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | N | Nanobody 35 | polymer | 138 | 15140.7 | 1 | Lama glama (Llama) | ||
5 | P | Calcitonin | polymer | 33 | 3420.9 | 1 | UniProt (P01258) In PDB | Homo sapiens | |
6 | R | Calcitonin receptor | polymer | 501 | 58469.6 | 1 | UniProt (P30988) Pfam (PF02793) Pfam (PF00002) In PDB | Homo sapiens (human) | CT-R |
7 | R | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
8 | R | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 2 | Chemie (Y01) |
Sequence modifications
A: 1 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
P: 1 - 32 (UniProt: P01258)
R: 25 - 474 (UniProt: P30988)
PDB | External Database | Details |
---|---|---|
Asn 54 | Ser 54 | conflict |
Ala 226 | Gly 226 | conflict |
Ala 268 | Glu 268 | conflict |
Lys 271 | Asn 271 | conflict |
Asp 274 | Lys 274 | conflict |
Lys 280 | Arg 280 | conflict |
Asp 284 | Thr 284 | conflict |
Thr 285 | Ile 285 | conflict |
Ser 366 | Ala 366 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Nh2 33 | - | amidation |
PDB | External Database | Details |
---|---|---|
Met -7 | - | expression tag |
Lys -6 | - | expression tag |
Thr -5 | - | expression tag |
Ile -4 | - | expression tag |
Ile -3 | - | expression tag |
Ala -2 | - | expression tag |
Leu -1 | - | expression tag |
Ser 0 | - | expression tag |
Tyr 1 | - | expression tag |
Ile 2 | - | expression tag |
Phe 3 | - | expression tag |
Cys 4 | - | expression tag |
Leu 5 | - | expression tag |
Val 6 | - | expression tag |
Phe 7 | - | expression tag |
Ala 8 | - | expression tag |
Asp 9 | - | expression tag |
Tyr 10 | - | expression tag |
Lys 11 | - | expression tag |
Asp 12 | - | expression tag |
Asp 13 | - | expression tag |
Asp 14 | - | expression tag |
Asp 15 | - | expression tag |
Leu 16 | - | expression tag |
Glu 17 | - | expression tag |
Val 18 | - | expression tag |
Leu 19 | - | expression tag |
Phe 20 | - | expression tag |
Gln 21 | - | expression tag |
Gly 22 | - | expression tag |
Pro 23 | - | expression tag |
Ala 24 | - | expression tag |
Leu 447 | Pro 447 | conflict |
Pro 475 | - | expression tag |
Ala 476 | - | expression tag |
Gly 477 | - | expression tag |
Leu 478 | - | expression tag |
Glu 479 | - | expression tag |
Val 480 | - | expression tag |
Leu 481 | - | expression tag |
Phe 482 | - | expression tag |
Gln 483 | - | expression tag |
Gly 484 | - | expression tag |
Pro 485 | - | expression tag |
His 486 | - | expression tag |
His 487 | - | expression tag |
His 488 | - | expression tag |
His 489 | - | expression tag |
His 490 | - | expression tag |
His 491 | - | expression tag |
His 492 | - | expression tag |
His 493 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 169125.8 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1194.7 | |
All* | Total formula weight | 170320.5 |