7TU9

Alpha1/BetaB Heteromeric Glycine Receptor in Strychnine-Bound State

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, D, C, B)	Glycine receptor subunit alphaZ1	polymer	458	52537.6	4	UniProt (O93430) Pfam (PF02931) Pfam (PF02932)	Danio rerio (zebrafish)
2	E (E)	Glycine receptor beta subunit 2	polymer	591	65820.3	1	UniProt (Q6DC22) Pfam (PF02931) Pfam (PF02932)	Danio rerio (zebrafish)	Glycine receptor,beta b
3	F, FA, GA, K, S... (A, E, D, C, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
4	AA, G, HA, IA, J... (B, A, E, D, C)	[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate	non-polymer		746.6	10	Chemie (PIO)
5	BA, CA, DA, EA, H... (B, E, A, D, C)	1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		678.9	10	Chemie (PX4)
6	I, L, T, W, X (A, D, C, B)	STRYCHNINE	non-polymer		334.4	5	Chemie (SY9)

Sequence modifications

A, D, C, B: 1 - 444 (UniProt: O93430)

PDB	External Database	Details
Leu 445	-	expression tag
Val 446	-	expression tag
Pro 447	-	expression tag
Arg 448	-	expression tag
Gly 449	-	expression tag
Ser 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag
His 458	-	expression tag

E: -80 - 494 (UniProt: Q6DC22)

PDB	External Database	Details
Trp -51	-	insertion
Ser -50	-	insertion
His -49	-	insertion
Pro -48	-	insertion
Gln -47	-	insertion
Phe -46	-	insertion
Glu -45	-	insertion
Lys -44	-	insertion
Gly -43	-	insertion
Gly -42	-	insertion
Gly -41	-	insertion
Ser -40	-	insertion
Gly -39	-	insertion
Gly -38	-	insertion
Gly -37	-	insertion
Ser -36	-	insertion
Gly -35	-	insertion
Gly -34	-	insertion
Gly -33	-	insertion
Ser -32	-	insertion
Trp -31	-	insertion
Ser -30	-	insertion
His -29	-	insertion
Pro -28	-	insertion
Gln -27	-	insertion
Phe -26	-	insertion
Glu -25	-	insertion
Lys -24	-	insertion
Gly -23	-	insertion
Gly -22	-	insertion
Gly -21	-	insertion
Ser -20	-	insertion
Gly -19	-	insertion
Gly -18	-	insertion
Gly -17	-	insertion
Ser -16	-	insertion
Gly -15	-	insertion
Gly -14	-	insertion
Gly -13	-	insertion
Ser -12	-	insertion
Trp -11	-	insertion
Ser -10	-	insertion
His -9	-	insertion
Pro -8	-	insertion
Gln -7	-	insertion
Phe -6	-	insertion
Glu -5	-	insertion
Lys -4	-	insertion
Gly -3	-	insertion
Gly -2	-	insertion
Gly -1	-	insertion
Ser 0	-	insertion
Gly 1	-	insertion
Gly 2	-	insertion
Gly 3	-	insertion
Ser 4	-	insertion
Gly 5	-	insertion
Gly 6	-	insertion
Gly 7	-	insertion
Ser 8	-	insertion
Trp 9	-	insertion
Ser 10	-	insertion
His 11	-	insertion
Pro 12	-	insertion
Gln 13	-	insertion
Phe 14	-	insertion
Glu 15	-	insertion
Lys 16	-	insertion
Glu 17	-	insertion
Asn 18	-	insertion
Leu 19	-	insertion
Tyr 20	-	insertion
Phe 21	-	insertion
Gln 22	-	insertion
Gly 23	-	insertion
Glu 24	-	insertion
Lys 25	-	insertion
Ser 26	-	insertion
Ala 27	-	insertion
Lys 28	-	insertion
Lys 29	-	insertion
Glu 495	-	expression tag
Asn 496	-	expression tag
Leu 497	-	expression tag
Tyr 498	-	expression tag
Phe 499	-	expression tag
Gln 500	-	expression tag
Gly 501	-	expression tag
Thr 502	-	expression tag
Glu 503	-	expression tag
Thr 504	-	expression tag
Ser 505	-	expression tag
Gln 506	-	expression tag
Val 507	-	expression tag
Ala 508	-	expression tag
Pro 509	-	expression tag
Ala 510	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	275970.7
Non-Polymers*	Number of molecules	31
	Total formula weight	17254.4
All*	Total formula weight	293225.0

*Water molecules are not included.