7TTL

Stable-5-LOX elongated Ha2 (4 copies ASU)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, D, B	Arachidonate 5-lipoxygenase	polymer	691	79436.2	4	UniProt (P09917) Pfam (PF01477) Pfam (PF00305) In PDB	Homo sapiens (human)	5-lipoxygenase
2	A, C, D, B	FE (II) ION	non-polymer		55.8	4	Chemie (FE2)
3		water	water		18.0	476	Chemie (HOH)

Sequence modifications

A, C, D, B: -6 - 673 (UniProt: P09917)

PDB	External Database	Details
Met -14	-	initiating methionine
Gly -13	-	expression tag
Ser -12	-	expression tag
Ser -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -6	-	expression tag
Ser -6	-	expression tag
Ser -6	-	expression tag
Gly -6	-	expression tag
Leu -6	-	expression tag
Val -6	-	expression tag
Pro -6	-	expression tag
Arg -6	-	expression tag
Gly -6	-	expression tag
Ser -6	-	expression tag
His -6	-	expression tag
Glu 16	Trp 14	conflict
His 17	Phe 15	conflict
-	Pro 41	deletion
-	Phe 42	deletion
-	Tyr 43	deletion
Gly 43	Asn 44	conflict
Ser 44	Asp 45	conflict
Gly 75	Trp 76	conflict
Ser 76	Leu 77	conflict
Ala 240	Cys 241	conflict
Ala 561	Cys 562	conflict
Glu 653	Lys 654	conflict
Asn 654	Lys 655	conflict
Leu 655	Lys 656	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	317745.0
Non-Polymers*	Number of molecules	4
	Total formula weight	223.4
All*	Total formula weight	317968.3

*Water molecules are not included.