7TSK
Structure of human endothelial nitric oxide synthase heme domain in complex with 4-methyl-6-(3-(methylamino)prop-1-yn-1-yl)pyridin-2-amine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Nitric oxide synthase, endothelial | polymer | 440 | 49345.8 | 4 | UniProt (P29474) Pfam (PF02898) In PDB | Homo sapiens (human) | Constitutive NOS,cNOS,EC-NOS,Endothelial NOS,eNOS,NOS type III,NOSIII |
2 | A, D, B, C | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
3 | A, D, B, C | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 4 | Chemie (H4B) | |||
4 | C, A, D, B | 4-methyl-6-[3-(methylamino)prop-1-yn-1-yl]pyridin-2-amine | non-polymer | 175.2 | 4 | Chemie (K9C) | |||
5 | C, A, D, B | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 10 | Chemie (BTB) | |||
6 | C, A, D, B | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
7 | C, A, D, B | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
8 | C, A, D, B | GADOLINIUM ATOM | non-polymer | 157.3 | 4 | Chemie (GD) | |||
9 | C, A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
10 | water | water | 18.0 | 611 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 41 - 480 (UniProt: P29474)
PDB | External Database | Details |
---|---|---|
Glu 298 | Asp 298 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 197383.1 | |
Non-Polymers* | Number of molecules | 38 |
Total formula weight | 7678.4 | |
All* | Total formula weight | 205061.5 |