Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7TS4

Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 4-methyl-6-(3-(4-methylpiperazin-1-yl)prop-1-yn-1-yl)pyridin-2-amine

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DNitric oxide synthase, brainpolymer42348996.84UniProt (P29475)
Pfam (PF02898)
In PDB
Homo sapiens (human)Constitutive NOS,NC-NOS,NOS type I,Neuronal NOS,nNOS,Peptidyl-cysteine S-nitrosylase NOS1,bNOS
2A, B, C, DPROTOPORPHYRIN IX CONTAINING FEnon-polymer616.54Chemie (HEM)
3A, B, C, D5,6,7,8-TETRAHYDROBIOPTERINnon-polymer241.24Chemie (H4B)
4A, B, C, D4-methyl-6-[3-(4-methylpiperazin-1-yl)prop-1-yn-1-yl]pyridin-2-aminenon-polymer244.34Chemie (K90)
5A, B, C, DGLYCEROLnon-polymer92.15Chemie (GOL)
6A, DZINC IONnon-polymer65.42Chemie (ZN)
7waterwater18.01354Chemie (HOH)
Sequence modifications
A, B, C, D: 302 - 722 (UniProt: P29475)
PDBExternal DatabaseDetails
Ala 354Arg 354engineered mutation
Asp 357Gly 357engineered mutation
Leu 723-expression tag
Val 724-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight195987.1
Non-Polymers*Number of molecules19
Total formula weight4999.6
All*Total formula weight200986.7
*Water molecules are not included.

221051

PDB entries from 2024-06-12

PDB statisticsPDBj update infoContact PDBjnumon