7TRJ
The eukaryotic translation initiation factor 2B from Homo sapiens with a H160D mutation in the beta subunit
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Translation initiation factor eIF-2B subunit epsilon | polymer | 721 | 80466.6 | 2 | UniProt (Q13144) Pfam (PF02020) In PDB | Homo sapiens (human) | eIF-2B GDP-GTP exchange factor subunit epsilon |
2 | D, C | Translation initiation factor eIF-2B subunit beta | polymer | 351 | 39016.5 | 2 | UniProt (P49770) Pfam (PF01008) In PDB | Homo sapiens (human) | S20I15,S20III15,eIF-2B GDP-GTP exchange factor subunit beta |
3 | E, F | Translation initiation factor eIF-2B subunit delta | polymer | 523 | 57640.2 | 2 | UniProt (Q9UI10) Pfam (PF01008) In PDB | Homo sapiens (human) | eIF-2B GDP-GTP exchange factor subunit delta |
4 | G, H | Translation initiation factor eIF-2B subunit alpha | polymer | 305 | 33754.1 | 2 | UniProt (Q14232) Pfam (PF01008) In PDB | Homo sapiens (human) | eIF-2B GDP-GTP exchange factor subunit alpha |
5 | I, J | Translation initiation factor eIF-2B subunit gamma | polymer | 452 | 50304.2 | 2 | UniProt (Q9NR50) Pfam (PF00483) In PDB | Homo sapiens (human) | eIF-2B GDP-GTP exchange factor subunit gamma |
Sequence modifications
D, C: 1 - 351 (UniProt: P49770)
PDB | External Database | Details |
---|---|---|
Asp 160 | His 160 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 10 |
Total formula weight | 522363.3 | |
All* | Total formula weight | 522363.3 |