7TRJ
The eukaryotic translation initiation factor 2B from Homo sapiens with a H160D mutation in the beta subunit
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F (A, B) | Translation initiation factor eIF-2B subunit epsilon | polymer | 721 | 80466.6 | 2 | UniProt (Q13144) Pfam (PF02020) | Homo sapiens (human) | eIF-2B GDP-GTP exchange factor subunit epsilon |
| 2 | B, G (D, C) | Translation initiation factor eIF-2B subunit beta | polymer | 351 | 39016.5 | 2 | UniProt (P49770) Pfam (PF01008) | Homo sapiens (human) | S20I15,S20III15,eIF-2B GDP-GTP exchange factor subunit beta |
| 3 | C, H (E, F) | Translation initiation factor eIF-2B subunit delta | polymer | 523 | 57640.2 | 2 | UniProt (Q9UI10) Pfam (PF01008) | Homo sapiens (human) | eIF-2B GDP-GTP exchange factor subunit delta |
| 4 | D, I (G, H) | Translation initiation factor eIF-2B subunit alpha | polymer | 305 | 33754.1 | 2 | UniProt (Q14232) Pfam (PF01008) | Homo sapiens (human) | eIF-2B GDP-GTP exchange factor subunit alpha |
| 5 | E, J (I, J) | Translation initiation factor eIF-2B subunit gamma | polymer | 452 | 50304.2 | 2 | UniProt (Q9NR50) Pfam (PF00483) | Homo sapiens (human) | eIF-2B GDP-GTP exchange factor subunit gamma |
Sequence modifications
D, C: 1 - 351 (UniProt: P49770)
| PDB | External Database | Details |
|---|---|---|
| Asp 160 | His 160 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 522363.3 | |
| All* | Total formula weight | 522363.3 |
