7TRJ

The eukaryotic translation initiation factor 2B from Homo sapiens with a H160D mutation in the beta subunit

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Translation initiation factor eIF-2B subunit epsilon	polymer	721	80466.6	2	UniProt (Q13144) Pfam (PF02020) In PDB	Homo sapiens (human)	eIF-2B GDP-GTP exchange factor subunit epsilon
2	D, C	Translation initiation factor eIF-2B subunit beta	polymer	351	39016.5	2	UniProt (P49770) Pfam (PF01008) In PDB	Homo sapiens (human)	S20I15,S20III15,eIF-2B GDP-GTP exchange factor subunit beta
3	E, F	Translation initiation factor eIF-2B subunit delta	polymer	523	57640.2	2	UniProt (Q9UI10) Pfam (PF01008) In PDB	Homo sapiens (human)	eIF-2B GDP-GTP exchange factor subunit delta
4	G, H	Translation initiation factor eIF-2B subunit alpha	polymer	305	33754.1	2	UniProt (Q14232) Pfam (PF01008) In PDB	Homo sapiens (human)	eIF-2B GDP-GTP exchange factor subunit alpha
5	I, J	Translation initiation factor eIF-2B subunit gamma	polymer	452	50304.2	2	UniProt (Q9NR50) Pfam (PF00483) In PDB	Homo sapiens (human)	eIF-2B GDP-GTP exchange factor subunit gamma

Sequence modifications

D, C: 1 - 351 (UniProt: P49770)

PDB	External Database	Details
Asp 160	His 160	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	522363.3
All*	Total formula weight	522363.3

*Water molecules are not included.