7TQP

Structure of human TREX1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Three-prime repair exonuclease 1	polymer	243	26281.1	1	UniProt (Q9NSU2)	Homo sapiens (human)	3'-5' exonuclease TREX1,Deoxyribonuclease III,DNase III
2	B, C, D, E (A)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
3	F (A)	water	water		18.0	137	Chemie (HOH)

Sequence modifications

A: 1 - 242 (UniProt: Q9NSU2)

PDB	External Database	Details
Ser 0	-	expression tag
Thr 5	Ala 5	engineered mutation
His 8	Pro 8	engineered mutation
His 10	Pro 10	engineered mutation
Leu 17	Phe 17	engineered mutation
Leu 19	Met 19	engineered mutation
Ser 26	Phe 26	engineered mutation
Arg 28	Gln 28	engineered mutation
Glu 30	Lys 30	engineered mutation
Arg 42	Cys 42	engineered mutation
Asn 46	Ser 46	engineered mutation
Thr 47	Pro 47	engineered mutation
Ser 48	Pro 48	engineered mutation
Ile 49	Thr 49	engineered mutation
His 53	Pro 53	engineered mutation
Pro 56	Thr 56	engineered mutation
Arg 59	Pro 59	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	26281.1
Non-Polymers*	Number of molecules	4
	Total formula weight	384.3
All*	Total formula weight	26665.4

*Water molecules are not included.