7TQ4
Structure of SARS-CoV-2 3CL protease in complex with the cyclopropane based inhibitor 6c
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | 3C-like proteinase | polymer | 309 | 34068.8 | 1 | UniProt (P0DTD1) Pfam (PF05409) In PDB | Severe acute respiratory syndrome coronavirus 2 | 3CL-PRO, 3CLp, Main protease, Mpro, Non-structural protein 5, nsp5, SARS coronavirus main proteinase |
2 | A | N~2~-({[(1R,2R)-2-(3-chlorophenyl)cyclopropyl]methoxy}carbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide | non-polymer | 478.0 | 1 | Chemie (IRZ) | |||
3 | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A: 1 - 305 (UniProt: P0DTD1)
PDB | External Database | Details |
---|---|---|
Ser -3 | - | expression tag |
Asn -2 | - | expression tag |
Ile -1 | - | expression tag |
Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34068.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 478.0 | |
All* | Total formula weight | 34546.8 |