7TOR
Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A18S) | 18S rRNA | polymer | 1698 | 548040.2 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 2 | B (A28S) | 28S rRNA | polymer | 3552 | 1151291.5 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 3 | C (A58S) | 5.8S rRNA | polymer | 151 | 48545.7 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 4 | D (A5S) | 5S rRNA | polymer | 120 | 38691.9 | 1 | GenBank (X06789.1) | Oryctolagus cuniculus (rabbit) | |
| 5 | E (AL02) | 60S ribosomal protein L8 | polymer | 248 | 26998.6 | 1 | UniProt (G1TT27) Pfam (PF00181) Pfam (PF03947) | Oryctolagus cuniculus (rabbit) | |
| 6 | F (AL03) | 60S ribosomal protein L3 | polymer | 394 | 45119.8 | 1 | UniProt (G1TL06) Pfam (PF00297) | Oryctolagus cuniculus (rabbit) | |
| 7 | G (AL04) | 60S ribosomal protein L4 | polymer | 362 | 41101.4 | 1 | UniProt (A0A5F9DCT1) Pfam (PF00573) Pfam (PF14374) | Oryctolagus cuniculus (rabbit) | |
| 8 | H (AL05) | 60S ribosomal protein L5 | polymer | 293 | 34077.4 | 1 | UniProt (G1SYJ6) UniProt (by SIFTS) (P19949) | Oryctolagus cuniculus (rabbit) | |
| 9 | I (AL06) | 60S ribosomal protein L6 | polymer | 251 | 28818.3 | 1 | UniProt (G1SKF7) Pfam (PF03868) Pfam (PF01159) | Oryctolagus cuniculus (rabbit) | |
| 10 | J (AL07) | 60S ribosomal protein L7 | polymer | 225 | 26658.8 | 1 | UniProt (G1SV32) Pfam (PF08079) Pfam (PF00327) | Oryctolagus cuniculus (rabbit) | |
| 11 | K (AL08) | eL8 | polymer | 233 | 26695.7 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 12 | L (AL09) | 60S ribosomal protein L9 | polymer | 190 | 21627.2 | 1 | UniProt (G1SWI6) Pfam (PF00347) | Oryctolagus cuniculus (rabbit) | |
| 13 | M (AL10) | Ribosomal protein L10 | polymer | 205 | 23737.0 | 1 | UniProt (B7NZQ2) Pfam (PF00252) | Oryctolagus cuniculus (rabbit) | Ribosomal protein L10 (Predicted) |
| 14 | N (AL11) | 60S ribosomal protein L11 | polymer | 170 | 19399.5 | 1 | UniProt (G1TUB8) Pfam (PF00281) Pfam (PF00673) | Oryctolagus cuniculus (rabbit) | |
| 15 | O (AL12) | uL11 | polymer | 153 | 16561.1 | 1 | UniProt (G1SMR7) Pfam (PF03946) Pfam (PF00298) | Oryctolagus cuniculus (rabbit) | |
| 16 | P (AL13) | 60S ribosomal protein L13 | polymer | 210 | 24200.5 | 1 | UniProt (G1TPV0) | Oryctolagus cuniculus (rabbit) | |
| 17 | Q (AL14) | 60S ribosomal protein L14 | polymer | 138 | 16217.4 | 1 | UniProt (U3KNW6) Pfam (PF01929) UniProt (by SIFTS) (G1SZ12) | Oryctolagus cuniculus (rabbit) | |
| 18 | R (AL15) | 60S ribosomal protein L15 | polymer | 203 | 24076.1 | 1 | UniProt (G1T0C1) Pfam (PF00827) | Oryctolagus cuniculus (rabbit) | |
| 19 | S (AL16) | uL13 | polymer | 199 | 23144.9 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 20 | T (AL17) | 60S ribosomal protein L17 | polymer | 153 | 17758.7 | 1 | UniProt (G1SCJ6) Pfam (PF00237) | Oryctolagus cuniculus (rabbit) | |
| 21 | U (AL18) | eL18 | polymer | 191 | 22099.1 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 22 | V (AL19) | 60S ribosomal protein L19 | polymer | 180 | 21613.0 | 1 | UniProt (G1TYL6) Pfam (PF01280) | Oryctolagus cuniculus (rabbit) | |
| 23 | W (AL20) | eL20 | polymer | 176 | 20827.6 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 24 | X (AL21) | 60S ribosomal protein L21 | polymer | 159 | 18478.8 | 1 | UniProt (G1SHQ2) Pfam (PF01157) | Oryctolagus cuniculus (rabbit) | |
| 25 | Y (AL22) | eL22 | polymer | 99 | 11495.3 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 26 | Z (AL23) | 60S ribosomal protein L23 | polymer | 131 | 13972.4 | 1 | UniProt (G1T6D1) Pfam (PF00238) | Oryctolagus cuniculus (rabbit) | |
| 27 | AA (AL24) | Ribosomal protein L24 | polymer | 121 | 14131.5 | 1 | UniProt (G1SE28) Pfam (PF01246) | Oryctolagus cuniculus (rabbit) | |
| 28 | BA (AL25) | uL23 | polymer | 118 | 13727.2 | 1 | Oryctolagus cuniculus | ||
| 29 | CA (AL26) | 60S ribosomal protein L26 | polymer | 134 | 15891.8 | 1 | UniProt (G1SQH0) Pfam (PF16906) Pfam (PF00467) | Oryctolagus cuniculus (rabbit) | |
| 30 | DA (AL27) | 60S ribosomal protein L27 | polymer | 135 | 15704.6 | 1 | UniProt (G1TXF6) Pfam (PF00467) Pfam (PF01777) | Oryctolagus cuniculus (rabbit) | |
| 31 | EA (AL28) | 60S ribosomal protein L27a | polymer | 147 | 16489.4 | 1 | UniProt (G1SNY0) Pfam (PF00828) | Oryctolagus cuniculus (rabbit) | |
| 32 | FA (AL29) | eL29 | polymer | 104 | 12093.4 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 33 | GA (AL30) | 60S ribosomal protein L30 | polymer | 98 | 10914.8 | 1 | UniProt (G1TDL2) Pfam (PF01248) | Oryctolagus cuniculus (rabbit) | |
| 34 | HA (AL31) | 60S ribosomal protein L31 | polymer | 107 | 12635.7 | 1 | UniProt (G1SHG0) Pfam (PF01198) | Oryctolagus cuniculus (rabbit) | |
| 35 | IA (AL32) | 60S ribosomal protein L32 | polymer | 128 | 15022.0 | 1 | UniProt (G1U437) Pfam (PF01655) UniProt (by SIFTS) (G1TUN8) | Oryctolagus cuniculus (rabbit) | |
| 36 | JA (AL33) | 60S ribosomal protein L35a | polymer | 109 | 12449.6 | 1 | UniProt (G1SF08) Pfam (PF01247) | Oryctolagus cuniculus (rabbit) | |
| 37 | KA (AL34) | 60S ribosomal protein L34 | polymer | 114 | 12994.6 | 1 | UniProt (G1TXG5) Pfam (PF01199) | Oryctolagus cuniculus (rabbit) | |
| 38 | LA (AL35) | 60S ribosomal protein L35 | polymer | 122 | 14435.4 | 1 | UniProt (G1SIT5) Pfam (PF00831) | Oryctolagus cuniculus (rabbit) | |
| 39 | MA (AL36) | 60S ribosomal protein L36 | polymer | 102 | 11888.4 | 1 | UniProt (G1TTQ5) Pfam (PF01158) | Oryctolagus cuniculus (rabbit) | |
| 40 | NA (AL37) | 60S ribosomal protein L37 | polymer | 86 | 10090.9 | 1 | UniProt (U3KPD5) Pfam (PF01907) | Oryctolagus cuniculus (rabbit) | |
| 41 | OA (AL38) | eL38 | polymer | 69 | 8107.8 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 42 | PA (AL39) | 60S ribosomal protein L39 | polymer | 50 | 6324.6 | 1 | UniProt (G1TTN1) Pfam (PF00832) | Oryctolagus cuniculus (rabbit) | |
| 43 | QA (AL40) | eL40 | polymer | 52 | 6199.6 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 44 | RA (AL41) | eL41 | polymer | 25 | 3473.5 | 1 | UniProt (A0A087WNH4) Pfam (PF05162) | Oryctolagus cuniculus (rabbit) | 60s ribosomal protein l41 |
| 45 | SA (AL42) | eL42 | polymer | 104 | 12198.6 | 1 | UniProt (A0A5F9D391) Pfam (PF00935) | Oryctolagus cuniculus (rabbit) | |
| 46 | TA (AL43) | 60S ribosomal protein L37a | polymer | 91 | 10168.2 | 1 | UniProt (G1SY53) Pfam (PF01780) | Oryctolagus cuniculus (rabbit) | |
| 47 | UA (ALNW) | 60S ribosomal protein L28 | polymer | 124 | 14220.7 | 1 | UniProt (G1U7L1) Pfam (PF01778) | Oryctolagus cuniculus (rabbit) | |
| 48 | VA (ALP0) | 60S acidic ribosomal protein P0 | polymer | 27 | 3299.0 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 49 | WA (ARAC) | Receptor of activated protein C kinase 1 | polymer | 313 | 34669.1 | 1 | UniProt (G1SJB4) Pfam (PF00400) | Oryctolagus cuniculus (rabbit) | |
| 50 | XA (AS00) | 40S_SA_C domain-containing protein | polymer | 217 | 24361.9 | 1 | UniProt (G1TJH8) Pfam (PF00318) | Oryctolagus cuniculus (rabbit) | |
| 51 | YA (AS01) | 40S ribosomal protein S3a | polymer | 213 | 24759.1 | 1 | UniProt (G1SS70) Pfam (PF01015) | Oryctolagus cuniculus (rabbit) | |
| 52 | ZA (AS02) | 40S ribosomal protein S2 | polymer | 221 | 24441.8 | 1 | UniProt (G1TUT9) | Oryctolagus cuniculus (rabbit) | |
| 53 | AB (AS03) | 40S ribosomal protein S3 | polymer | 228 | 25215.6 | 1 | UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189) | Oryctolagus cuniculus (rabbit) | |
| 54 | BB (AS04) | 40S ribosomal protein S4 | polymer | 262 | 29523.7 | 1 | UniProt (G1TA47) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) | Oryctolagus cuniculus (rabbit) | |
| 55 | CB (AS05) | Ribosomal protein S5 | polymer | 191 | 21525.9 | 1 | UniProt (G1TFM5) Pfam (PF00177) | Oryctolagus cuniculus (rabbit) | |
| 56 | DB (AS06) | 40S ribosomal protein S6 | polymer | 237 | 27471.5 | 1 | UniProt (G1TM55) Pfam (PF01092) | Oryctolagus cuniculus (rabbit) | |
| 57 | EB (AS07) | eS7 | polymer | 189 | 21629.3 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 58 | FB (AS08) | 40S ribosomal protein S8 | polymer | 206 | 24003.0 | 1 | UniProt (G1TJW1) Pfam (PF01201) | Oryctolagus cuniculus (rabbit) | |
| 59 | GB (AS09) | 40S ribosomal protein S9 | polymer | 185 | 21649.6 | 1 | UniProt (B7NZS8) Pfam (PF00163) Pfam (PF01479) | Oryctolagus cuniculus (rabbit) | |
| 60 | HB (AS10) | 40S ribosomal protein S10 | polymer | 96 | 11529.7 | 1 | UniProt (G1TPV3) Pfam (PF03501) | Oryctolagus cuniculus (rabbit) | |
| 61 | IB (AS11) | 40S ribosomal protein S11 | polymer | 151 | 17586.8 | 1 | UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366) | Oryctolagus cuniculus (rabbit) | |
| 62 | JB (AS12) | 40S ribosomal protein S12 | polymer | 117 | 13048.2 | 1 | UniProt (G1SFR8) Pfam (PF01248) | Oryctolagus cuniculus (rabbit) | |
| 63 | KB (AS13) | 40S ribosomal protein S13 | polymer | 149 | 17057.1 | 1 | UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312) | Oryctolagus cuniculus (rabbit) | |
| 64 | LB (AS14) | uS11 | polymer | 135 | 14431.5 | 1 | UniProt (G1U472) Pfam (PF00411) UniProt (by SIFTS) (G1T1F0) | Oryctolagus cuniculus (rabbit) | |
| 65 | MB (AS15) | 40S ribosomal protein S15 | polymer | 120 | 14246.9 | 1 | UniProt (G1U0Q2) Pfam (PF00203) | Oryctolagus cuniculus (rabbit) | |
| 66 | NB (AS16) | uS9 | polymer | 142 | 16032.8 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 67 | OB (AS17) | 40S ribosomal protein S17 | polymer | 132 | 15250.7 | 1 | UniProt (G1TU13) Pfam (PF00833) | Oryctolagus cuniculus (rabbit) | |
| 68 | PB (AS18) | 40S ribosomal protein S18 | polymer | 144 | 16898.6 | 1 | UniProt (G1TPG3) Pfam (PF00416) | Oryctolagus cuniculus (rabbit) | |
| 69 | QB (AS19) | eS19 | polymer | 141 | 15611.0 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 70 | RB (AS20) | 40S ribosomal protein S20 | polymer | 100 | 11395.5 | 1 | UniProt (G1SIZ2) Pfam (PF00338) | Oryctolagus cuniculus (rabbit) | |
| 71 | SB (AS21) | eS21 | polymer | 83 | 9124.4 | 1 | UniProt (G1TM82) Pfam (PF01249) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S21 |
| 72 | TB (AS22) | 40S ribosomal protein S15a | polymer | 129 | 14734.4 | 1 | UniProt (G1TG89) Pfam (PF00410) | Oryctolagus cuniculus (rabbit) | |
| 73 | UB (AS23) | 40S ribosomal protein S23 | polymer | 141 | 15626.4 | 1 | UniProt (G1SZ47) Pfam (PF00164) | Oryctolagus cuniculus (rabbit) | |
| 74 | VB (AS24) | 40S ribosomal protein S24 | polymer | 124 | 14432.1 | 1 | UniProt (G1T3D8) Pfam (PF01282) | Oryctolagus cuniculus (rabbit) | |
| 75 | WB (AS25) | 40S ribosomal protein S25 | polymer | 75 | 8526.1 | 1 | UniProt (G1TDB3) Pfam (PF03297) | Oryctolagus cuniculus (rabbit) | |
| 76 | XB (AS26) | eS26 | polymer | 101 | 11645.8 | 1 | UniProt (G1TFE8) Pfam (PF01283) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S26 |
| 77 | YB (AS27) | 40S ribosomal protein S27 | polymer | 83 | 9349.0 | 1 | UniProt (G1TZ76) Pfam (PF01667) | Oryctolagus cuniculus (rabbit) | |
| 78 | ZB (AS28) | 40S ribosomal protein S28 | polymer | 62 | 7007.1 | 1 | UniProt (G1TIB4) Pfam (PF01200) | Oryctolagus cuniculus (rabbit) | |
| 79 | AC (AS29) | 40S ribosomal protein S29 | polymer | 55 | 6559.6 | 1 | UniProt (G1U7M4) Pfam (PF00253) | Oryctolagus cuniculus (rabbit) | |
| 80 | BC (AS30) | 40S ribosomal protein S30 | polymer | 55 | 6317.5 | 1 | UniProt (G1T8A2) Pfam (PF04758) | Oryctolagus cuniculus (rabbit) | |
| 81 | CC (AS31) | 40S ribosomal protein S27a | polymer | 68 | 7986.4 | 1 | UniProt (G1SK22) Pfam (PF00240) Pfam (PF01599) | Oryctolagus cuniculus (rabbit) | |
| 82 | DC, HC (ETRN, PTRN) | tRNAfMet bound to E-site | polymer | 77 | 24802.8 | 2 | GenBank (1275521620) | Escherichia coli K-12 | |
| 83 | EC, FC (GR1, GR2) | GR20, ALS/FTD dipeptide repeat protein | polymer | 40 | 4302.9 | 2 | Homo sapiens | ||
| 84 | GC (MRNA) | mRNA | polymer | 28 | 8591.2 | 1 | Saccharomyces cerevisiae | ||
| 85 | IC, JC, KC, LC, MC... (AL34, AL37, AL40, AL42, AL43...) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) |
Sequence modifications
A5S: 1 - 120 (GenBank: X06789.1)
AL10: 2 - 214 (UniProt: B7NZQ2)
AL13: 2 - 211 (UniProt: G1TPV0)
AL19: 2 - 181 (UniProt: G1TYL6)
AS02: 58 - 278 (UniProt: G1TUT9)
AS08: 2 - 207 (UniProt: G1TJW1)
AS21: 1 - 83 (UniProt: G1TM82)
AS26: 2 - 102 (UniProt: G1TFE8)
| PDB | External Database | Details |
|---|---|---|
| U 2 | N 2 | conflict |
| C 36 | N 36 | conflict |
| U 102 | N 102 | conflict |
| U 112 | N 112 | conflict |
| U 114 | N 114 | conflict |
| U 119 | C 119 | conflict |
| U 120 | N 120 | conflict |
| PDB | External Database | Details |
|---|---|---|
| - | Leu 103 | deletion |
| - | Ser 104 | deletion |
| - | Cys 105 | deletion |
| - | Ala 106 | deletion |
| - | Gly 107 | deletion |
| - | Ala 108 | deletion |
| - | Asp 109 | deletion |
| - | Arg 110 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Ile 46 | - | insertion |
| Ala 47 | - | insertion |
| Pro 48 | - | insertion |
| Arg 49 | - | insertion |
| Pro 50 | - | insertion |
| Ala 51 | - | insertion |
| Ala 52 | - | insertion |
| Gly 53 | - | insertion |
| Pro 54 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Arg 38 | His 38 | conflict |
| Arg 151 | His 151 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 73 | Val 50 | conflict |
| Ser 101 | Ala 78 | conflict |
| Gly 119 | Ala 96 | conflict |
| Arg 194 | His 171 | conflict |
| Met 215 | Leu 192 | conflict |
| Arg 227 | Trp 204 | conflict |
| Gly 228 | Ser 205 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 47 | Gly 47 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 3 | Ser 3 | conflict |
| Asp 4 | Asn 4 | conflict |
| Gln 33 | Pro 33 | conflict |
| Phe 50 | Ser 50 | conflict |
| Ala 75 | Ser 75 | conflict |
| Asp 76 | His 76 | conflict |
| Lys 81 | Gln 81 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 28 | Cys 28 | conflict |
| Ala 56 | Val 56 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 86 |
| Total formula weight | 3184159.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 392.5 | |
| All* | Total formula weight | 3184552.2 |
