7TOQ
Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A18S | 18S rRNA | polymer | 1698 | 548024.2 | 1 | GenBank (6R6P_K) | Oryctolagus cuniculus (rabbit) | |
| 2 | A25S | 28S rRNA | polymer | 3649 | 1182428.0 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 3 | A58S | 5.8S rRNA | polymer | 156 | 50143.6 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 4 | A5S | 5S rRNA | polymer | 120 | 38691.9 | 1 | GenBank (X06789.1) | Oryctolagus cuniculus (rabbit) | |
| 5 | AL02 | uL2 | polymer | 244 | 26570.1 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 6 | AL03 | 60S ribosomal protein L3 | polymer | 394 | 45119.8 | 1 | UniProt (G1TL06) Pfam (PF00297) In PDB | Oryctolagus cuniculus (rabbit) | |
| 7 | AL04 | 60S ribosomal protein L4 | polymer | 362 | 41101.4 | 1 | UniProt (A0A5F9DCT1) Pfam (PF00573) Pfam (PF14374) In PDB | Oryctolagus cuniculus (rabbit) | |
| 8 | AL05 | 60S ribosomal protein L5 | polymer | 293 | 34077.4 | 1 | UniProt (G1SYJ6) UniProt (by SIFTS) (P19949) In PDB | Oryctolagus cuniculus (rabbit) | |
| 9 | AL06 | 60S ribosomal protein L6 | polymer | 251 | 28818.3 | 1 | UniProt (G1SKF7) Pfam (PF03868) Pfam (PF01159) In PDB | Oryctolagus cuniculus (rabbit) | |
| 10 | AL07 | uL30 | polymer | 225 | 26662.8 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 11 | AL08 | eL8 | polymer | 241 | 27480.6 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 12 | AL09 | 60S ribosomal protein L9 | polymer | 190 | 21627.2 | 1 | UniProt (G1SWI6) Pfam (PF00347) In PDB | Oryctolagus cuniculus (rabbit) | |
| 13 | AL10 | Ribosomal protein L10 | polymer | 213 | 24511.9 | 1 | UniProt (B7NZQ2) Pfam (PF00252) In PDB | Oryctolagus cuniculus (rabbit) | Ribosomal protein L10 (Predicted) |
| 14 | AL11 | 60S ribosomal protein L11 | polymer | 169 | 19270.3 | 1 | UniProt (G1TUB8) Pfam (PF00673) Pfam (PF00281) In PDB | Oryctolagus cuniculus (rabbit) | |
| 15 | AL12 | 60S ribosomal protein L12 | polymer | 163 | 17689.5 | 1 | UniProt (G1SMR7) Pfam (PF03946) Pfam (PF00298) In PDB | Oryctolagus cuniculus (rabbit) | |
| 16 | AL13 | eL13 | polymer | 210 | 24216.5 | 1 | UniProt (G1TKB3) Pfam (PF01294) In PDB | Oryctolagus cuniculus (rabbit) | |
| 17 | AL14 | 60S ribosomal protein L14 | polymer | 138 | 16217.4 | 1 | UniProt (U3KNW6) Pfam (PF01929) UniProt (by SIFTS) (G1SZ12) In PDB | Oryctolagus cuniculus (rabbit) | |
| 18 | AL15 | 60S ribosomal protein L15 | polymer | 203 | 24076.1 | 1 | UniProt (G1T0C1) Pfam (PF00827) In PDB | Oryctolagus cuniculus (rabbit) | |
| 19 | AL16 | uL13 | polymer | 199 | 23248.9 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 20 | AL17 | 60S ribosomal protein L17 | polymer | 153 | 17758.7 | 1 | UniProt (G1SCJ6) Pfam (PF00237) In PDB | Oryctolagus cuniculus (rabbit) | |
| 21 | AL18 | eL18 | polymer | 187 | 21457.4 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 22 | AL19 | 60S ribosomal protein L19 | polymer | 180 | 21613.0 | 1 | UniProt (G1TYL6) Pfam (PF01280) In PDB | Oryctolagus cuniculus (rabbit) | |
| 23 | AL20 | eL20 | polymer | 175 | 20696.4 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 24 | AL21 | 60S ribosomal protein L21 | polymer | 159 | 18478.8 | 1 | UniProt (G1SHQ2) Pfam (PF01157) In PDB | Oryctolagus cuniculus (rabbit) | |
| 25 | AL22 | eL22 | polymer | 99 | 11481.2 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 26 | AL23 | 60S ribosomal protein L23 | polymer | 131 | 13972.4 | 1 | UniProt (G1T6D1) Pfam (PF00238) In PDB | Oryctolagus cuniculus (rabbit) | |
| 27 | AL24 | Ribosomal protein L24 | polymer | 63 | 7512.8 | 1 | UniProt (G1SE28) Pfam (PF01246) In PDB | Oryctolagus cuniculus (rabbit) | |
| 28 | AL25 | uL23 | polymer | 119 | 13856.4 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 29 | AL26 | 60S ribosomal protein L26 | polymer | 134 | 15891.8 | 1 | UniProt (G1SQH0) Pfam (PF16906) Pfam (PF00467) In PDB | Oryctolagus cuniculus (rabbit) | |
| 30 | AL27 | 60S ribosomal protein L27 | polymer | 135 | 15704.6 | 1 | UniProt (G1TXF6) Pfam (PF00467) Pfam (PF01777) In PDB | Oryctolagus cuniculus (rabbit) | |
| 31 | AL28 | 60S ribosomal protein L27a | polymer | 147 | 16489.4 | 1 | UniProt (G1SNY0) Pfam (PF00828) In PDB | Oryctolagus cuniculus (rabbit) | |
| 32 | AL29 | eL29 | polymer | 103 | 11994.3 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 33 | AL30 | eL30 | polymer | 94 | 10496.4 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 34 | AL31 | 60S ribosomal protein L31 | polymer | 107 | 12635.7 | 1 | UniProt (G1SHG0) Pfam (PF01198) In PDB | Oryctolagus cuniculus (rabbit) | |
| 35 | AL32 | 60S ribosomal protein L32 | polymer | 128 | 15022.0 | 1 | UniProt (G1U437) Pfam (PF01655) UniProt (by SIFTS) (G1TUN8) In PDB | Oryctolagus cuniculus (rabbit) | |
| 36 | AL33 | 60S ribosomal protein L35a | polymer | 109 | 12449.6 | 1 | UniProt (G1SF08) Pfam (PF01247) In PDB | Oryctolagus cuniculus (rabbit) | |
| 37 | AL34 | 60S ribosomal protein L34 | polymer | 114 | 12994.6 | 1 | UniProt (G1TXG5) Pfam (PF01199) In PDB | Oryctolagus cuniculus (rabbit) | |
| 38 | AL35 | 60S ribosomal protein L35 | polymer | 122 | 14435.4 | 1 | UniProt (G1SIT5) Pfam (PF00831) In PDB | Oryctolagus cuniculus (rabbit) | |
| 39 | AL36 | 60S ribosomal protein L36 | polymer | 102 | 11888.4 | 1 | UniProt (G1TTQ5) Pfam (PF01158) In PDB | Oryctolagus cuniculus (rabbit) | |
| 40 | AL37 | 60S ribosomal protein L37 | polymer | 86 | 10090.9 | 1 | UniProt (U3KPD5) Pfam (PF01907) In PDB | Oryctolagus cuniculus (rabbit) | |
| 41 | AL38 | eL38 | polymer | 69 | 8107.8 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 42 | AL39 | eL39 | polymer | 50 | 6295.6 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 43 | AL40 | eL40 | polymer | 52 | 6199.6 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 44 | AL41 | eL41 | polymer | 23 | 3213.1 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 45 | AL42 | eL42 | polymer | 104 | 12198.6 | 1 | UniProt (A0A5F9D391) Pfam (PF00935) In PDB | Oryctolagus cuniculus (rabbit) | |
| 46 | AL43 | 60S ribosomal protein L37a | polymer | 91 | 10168.2 | 1 | UniProt (G1SY53) Pfam (PF01780) In PDB | Oryctolagus cuniculus (rabbit) | |
| 47 | ALP0 | 60S acidic ribosomal protein P0 | polymer | 27 | 3299.0 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 48 | ARAC | Receptor of activated protein C kinase 1 | polymer | 313 | 34669.1 | 1 | UniProt (G1SJB4) Pfam (PF00400) In PDB | Oryctolagus cuniculus (rabbit) | |
| 49 | AS00 | 40S_SA_C domain-containing protein | polymer | 217 | 24361.9 | 1 | UniProt (G1TJH8) Pfam (PF00318) In PDB | Oryctolagus cuniculus (rabbit) | |
| 50 | AS01 | 40S ribosomal protein S3a | polymer | 213 | 24759.1 | 1 | UniProt (G1SS70) Pfam (PF01015) In PDB | Oryctolagus cuniculus (rabbit) | |
| 51 | AS02 | 40S ribosomal protein S2 | polymer | 221 | 24441.8 | 1 | UniProt (G1TUT9) In PDB | Oryctolagus cuniculus (rabbit) | |
| 52 | AS03 | 40S ribosomal protein S3 | polymer | 228 | 25215.6 | 1 | UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189) In PDB | Oryctolagus cuniculus (rabbit) | |
| 53 | AS04 | 40S ribosomal protein S4 | polymer | 262 | 29523.7 | 1 | UniProt (G1TA47) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) In PDB | Oryctolagus cuniculus (rabbit) | |
| 54 | AS05 | Ribosomal protein S5 | polymer | 191 | 21525.9 | 1 | UniProt (G1TFM5) Pfam (PF00177) In PDB | Oryctolagus cuniculus (rabbit) | |
| 55 | AS06 | 40S ribosomal protein S6 | polymer | 237 | 27471.5 | 1 | UniProt (G1TM55) Pfam (PF01092) In PDB | Oryctolagus cuniculus (rabbit) | |
| 56 | AS07 | eS7 | polymer | 189 | 21629.3 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 57 | AS08 | 40S ribosomal protein S8 | polymer | 206 | 24003.0 | 1 | UniProt (G1TJW1) Pfam (PF01201) In PDB | Oryctolagus cuniculus (rabbit) | |
| 58 | AS09 | 40S ribosomal protein S9 | polymer | 185 | 21649.6 | 1 | UniProt (B7NZS8) Pfam (PF00163) Pfam (PF01479) In PDB | Oryctolagus cuniculus (rabbit) | |
| 59 | AS10 | 40S ribosomal protein S10 | polymer | 96 | 11529.7 | 1 | UniProt (G1TPV3) Pfam (PF03501) In PDB | Oryctolagus cuniculus (rabbit) | |
| 60 | AS11 | 40S ribosomal protein S11 | polymer | 151 | 17586.8 | 1 | UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366) In PDB | Oryctolagus cuniculus (rabbit) | |
| 61 | AS12 | 40S ribosomal protein S12 | polymer | 117 | 13048.2 | 1 | UniProt (G1SFR8) Pfam (PF01248) In PDB | Oryctolagus cuniculus (rabbit) | |
| 62 | AS13 | 40S ribosomal protein S13 | polymer | 149 | 17057.1 | 1 | UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312) In PDB | Oryctolagus cuniculus (rabbit) | |
| 63 | AS14 | 40S ribosomal protein S14 | polymer | 136 | 14544.7 | 1 | UniProt (G1U472) Pfam (PF00411) UniProt (by SIFTS) (G1T1F0) In PDB | Oryctolagus cuniculus (rabbit) | |
| 64 | AS15 | 40S ribosomal protein S15 | polymer | 120 | 14246.9 | 1 | UniProt (G1U0Q2) Pfam (PF00203) In PDB | Oryctolagus cuniculus (rabbit) | |
| 65 | AS16 | uS9 | polymer | 142 | 16032.8 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 66 | AS17 | 40S ribosomal protein S17 | polymer | 132 | 15250.7 | 1 | UniProt (G1TU13) Pfam (PF00833) In PDB | Oryctolagus cuniculus (rabbit) | |
| 67 | AS18 | 40S ribosomal protein S18 | polymer | 144 | 16898.6 | 1 | UniProt (G1TPG3) Pfam (PF00416) In PDB | Oryctolagus cuniculus (rabbit) | |
| 68 | AS19 | eS19 | polymer | 141 | 15611.0 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 69 | AS20 | 40S ribosomal protein S20 | polymer | 100 | 11395.5 | 1 | UniProt (G1SIZ2) Pfam (PF00338) In PDB | Oryctolagus cuniculus (rabbit) | |
| 70 | AS21 | eS21 | polymer | 83 | 9124.4 | 1 | UniProt (G1TM82) Pfam (PF01249) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S21 |
| 71 | AS22 | 40S ribosomal protein S15a | polymer | 129 | 14734.4 | 1 | UniProt (G1TG89) Pfam (PF00410) In PDB | Oryctolagus cuniculus (rabbit) | |
| 72 | AS23 | 40S ribosomal protein S23 | polymer | 141 | 15626.4 | 1 | UniProt (G1SZ47) Pfam (PF00164) In PDB | Oryctolagus cuniculus (rabbit) | |
| 73 | AS24 | 40S ribosomal protein S24 | polymer | 124 | 14432.1 | 1 | UniProt (G1T3D8) Pfam (PF01282) In PDB | Oryctolagus cuniculus (rabbit) | |
| 74 | AS25 | 40S ribosomal protein S25 | polymer | 75 | 8526.1 | 1 | UniProt (G1TDB3) Pfam (PF03297) In PDB | Oryctolagus cuniculus (rabbit) | |
| 75 | AS26 | eS26 | polymer | 101 | 11645.8 | 1 | UniProt (G1TFE8) Pfam (PF01283) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S26 |
| 76 | AS27 | 40S ribosomal protein S27 | polymer | 83 | 9349.0 | 1 | UniProt (G1TZ76) Pfam (PF01667) In PDB | Oryctolagus cuniculus (rabbit) | |
| 77 | AS28 | 40S ribosomal protein S28 | polymer | 62 | 7007.1 | 1 | UniProt (G1TIB4) Pfam (PF01200) In PDB | Oryctolagus cuniculus (rabbit) | |
| 78 | AS29 | 40S ribosomal protein S29 | polymer | 55 | 6559.6 | 1 | UniProt (G1U7M4) Pfam (PF00253) In PDB | Oryctolagus cuniculus (rabbit) | |
| 79 | AS30 | 40S ribosomal protein S30 | polymer | 55 | 6317.5 | 1 | UniProt (G1T8A2) Pfam (PF04758) In PDB | Oryctolagus cuniculus (rabbit) | |
| 80 | AS31 | 40S ribosomal protein S27a | polymer | 68 | 7986.4 | 1 | UniProt (G1SK22) Pfam (PF00240) Pfam (PF01599) In PDB | Oryctolagus cuniculus (rabbit) | |
| 81 | EL28 | 60S ribosomal protein L28 | polymer | 125 | 14319.8 | 1 | UniProt (G1U7L1) Pfam (PF01778) In PDB | Oryctolagus cuniculus (rabbit) | |
| 82 | MRNA | RNA (5'-R(*CP*AP*CP*AP*UP*GP*UP*UP*CP*C)-3') | polymer | 10 | 3097.9 | 1 | Saccharomyces cerevisiae | ||
| 83 | PR | PR20, ALS/FTD dipeptide repeat protein | polymer | 40 | 5104.2 | 1 | Homo sapiens | ||
| 84 | PTRN | tRNAfMet | polymer | 77 | 24802.8 | 1 | GenBank (1275521620) | Escherichia coli K-12 | |
| 85 | AL37, AL40, AL42, AL43 | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) |
Sequence modifications
A5S: 1 - 120 (GenBank: X06789.1)
AL13: 2 - 211 (UniProt: G1TKB3)
AL19: 2 - 181 (UniProt: G1TYL6)
AS02: 58 - 278 (UniProt: G1TUT9)
AS08: 2 - 207 (UniProt: G1TJW1)
AS21: 1 - 83 (UniProt: G1TM82)
AS26: 2 - 102 (UniProt: G1TFE8)
| PDB | External Database | Details |
|---|---|---|
| U 2 | N 2 | conflict |
| C 36 | N 36 | conflict |
| U 102 | N 102 | conflict |
| U 112 | N 112 | conflict |
| U 114 | N 114 | conflict |
| U 119 | C 119 | conflict |
| U 120 | N 120 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ser 52 | Ala 52 | conflict |
| Leu 55 | Ile 55 | conflict |
| Arg 74 | His 74 | conflict |
| Arg 190 | His 190 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 38 | His 38 | conflict |
| Arg 151 | His 151 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 73 | Val 50 | conflict |
| Ser 101 | Ala 78 | conflict |
| Gly 119 | Ala 96 | conflict |
| Arg 194 | His 171 | conflict |
| Met 215 | Leu 192 | conflict |
| Arg 227 | Trp 204 | conflict |
| Gly 228 | Ser 205 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 47 | Gly 47 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 3 | Ser 3 | conflict |
| Asp 4 | Asn 4 | conflict |
| Gln 33 | Pro 33 | conflict |
| Phe 50 | Ser 50 | conflict |
| Ala 75 | Ser 75 | conflict |
| Asp 76 | His 76 | conflict |
| Lys 81 | Gln 81 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 28 | Cys 28 | conflict |
| Ala 56 | Val 56 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 84 |
| Total formula weight | 3177463.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 3177725.5 |
