7TNW

Structural and functional impact by SARS-CoV-2 Omicron spike mutations

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (C, A, B)	Spike glycoprotein	polymer	1270	141490.1	3	UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601)	Severe acute respiratory syndrome coronavirus 2	S glycoprotein,E2,Peplomer protein
2	BA, D, EA, F, I... (b, D, e, F, I...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	9	In PDB GlyTouCan (G42666HT)
3	AA, CA, DA, E, FA... (a, c, d, E, f...)	alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	21	In PDB GlyTouCan (G62182OO)
4	HA, L, W (h, L, W)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	3	In PDB GlyTouCan (G21290RB)
5	AB, BB, CB, DB, EB... (B, C, A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	21	Chemie (NAG)

Sequence modifications

C, A, B: 1 - 1273 (UniProt: P0DTC2)

PDB	External Database	Details
Val 67	Ala 67	variant
-	His 69	deletion
-	Val 70	deletion
Ile 95	Thr 95	variant
-	Leu 141	deletion
-	Gly 142	deletion
-	Val 143	deletion
Phe 144	Tyr 144	variant
Asp 145	Tyr 145	variant
Ile 212	-	insertion
Val 213	-	insertion
Arg 214	Asn 211	variant
Glu 214	Leu 212	variant
Pro 214	Val 213	variant
Glu 214	Arg 214	variant
Asp 339	Gly 339	variant
Leu 371	Ser 371	variant
Pro 373	Ser 373	variant
Phe 375	Ser 375	variant
Asn 417	Lys 417	variant
Lys 440	Asn 440	variant
Ser 446	Gly 446	variant
Asn 477	Ser 477	variant
Lys 478	Thr 478	variant
Ala 484	Glu 484	variant
Arg 493	Gln 493	variant
Ser 496	Gly 496	variant
Arg 498	Gln 498	variant
Tyr 501	Asn 501	variant
His 505	Tyr 505	variant
Lys 547	Thr 547	variant
Gly 614	Asp 614	variant
Tyr 655	His 655	variant
Lys 679	Asn 679	variant
His 681	Pro 681	variant
Lys 764	Asn 764	variant
Tyr 796	Asp 796	variant
Lys 856	Asn 856	variant
His 954	Gln 954	variant
Lys 969	Asn 969	variant
Phe 981	Leu 981	variant

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	424470.4
Branched	Number of molecules	33
	Total formula weight	17848.6
Non-Polymers*	Number of molecules	21
	Total formula weight	4645.4
All*	Total formula weight	446964.4

*Water molecules are not included.