7TNO

Complex GGGN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Isoform Flip of Glutamate receptor 2,Voltage-dependent calcium channel gamma-3 subunit chimera	polymer	1033	115444.9	4	UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00822) UniProt (by SIFTS) (Q71RJ2)	Rattus norvegicus (Norway rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	E, G, I (A, B, C)	GLUTAMIC ACID	non-polymer		147.1	3	Chemie (GLU) PubChem (611) PubChem (23327) PubChem (33032)
3	F, H, J, K (A, B, C, D)	CYCLOTHIAZIDE	non-polymer		389.9	4	Chemie (CYZ) PubChem (2910) PubChem (657321) PubChem (5288009) PubChem (6603794) PubChem (11972587) PubChem (21550932) PubChem (44582559) PubChem (177678892) PubChem (52949708) PubChem (92142359) PubChem (98047041) PubChem (101691639) PubChem (5388988) PubChem (92143401) PubChem (92215537) PubChem (98047042) PubChem (101691640) PubChem (131842006)

Sequence modifications

A, B, C, D: 10 - 998 (UniProt: P19491)

PDB	External Database	Details
Glu 241	Asn 256	conflict
Leu 382	Val 397	conflict
-	Leu 399	deletion
-	Thr 400	deletion
-	Glu 401	deletion
-	Leu 402	deletion
-	Pro 403	deletion
-	Ser 404	deletion
Glu 384	Gly 405	conflict
Asp 385	Asn 406	conflict
Gln 392	Asn 413	conflict
Gly 999	-	linker
Thr 1000	-	linker

A, B, C, D: 1001 - 1214 (PDB: 7TNO)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	461779.7
Non-Polymers*	Number of molecules	7
	Total formula weight	2000.9
All*	Total formula weight	463780.6

*Water molecules are not included.