7TNK
Complex GNNN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Isoform Flip of Glutamate receptor 2,Voltage-dependent calcium channel gamma-3 subunit chimera | polymer | 1033 | 115444.9 | 4 | UniProt (P19491) UniProt (Q8VHX0) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00822) | Rattus norvegicus (Norway rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Neuronal voltage-gated calcium channel gamma-3 subunit,Transmembrane AMPAR regulatory protein gamma-3,TARP gamma-3 |
| 2 | E (A) | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | |||
| 3 | F, G, H, I (A, B, C, D) | CYCLOTHIAZIDE | non-polymer | 389.9 | 4 | Chemie (CYZ) |
Sequence modifications
A, B, C, D: 10 - 998 (UniProt: P19491)
A, B, C, D: 1004 - 1207 (UniProt: Q8VHX0)
| PDB | External Database | Details |
|---|---|---|
| Glu 241 | Asn 256 | conflict |
| Leu 382 | Val 397 | conflict |
| - | Leu 399 | deletion |
| - | Thr 400 | deletion |
| - | Glu 401 | deletion |
| - | Leu 402 | deletion |
| - | Pro 403 | deletion |
| - | Ser 404 | deletion |
| Glu 384 | Gly 405 | conflict |
| Asp 385 | Asn 406 | conflict |
| Gln 392 | Asn 413 | conflict |
| Gly 999 | - | linker |
| Thr 1000 | - | linker |
| Gly 1001 | - | linker |
| Leu 1002 | - | linker |
| Phe 1003 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Val 1007 | Ile 8 | conflict |
| Leu 1011 | Ile 12 | conflict |
| Lys 1040 | Arg 41 | conflict |
| Val 1044 | Thr 45 | conflict |
| Glu 1046 | Asp 47 | conflict |
| Asp 1047 | Asn 48 | conflict |
| Lys 1051 | Arg 52 | conflict |
| Asn 1071 | Ala 72 | conflict |
| Lys 1073 | Arg 74 | conflict |
| Leu 1075 | Val 76 | conflict |
| Gln 1078 | Lys 79 | conflict |
| Ala 1090 | Gln 91 | conflict |
| Phe 1096 | Leu 97 | conflict |
| Ile 1105 | Val 106 | conflict |
| Ile 1112 | Thr 113 | conflict |
| Met 1116 | Phe 117 | conflict |
| Ile 1121 | Val 122 | conflict |
| Tyr 1127 | His 128 | conflict |
| Lys 1128 | Arg 129 | conflict |
| Thr 1129 | Ser 130 | conflict |
| Asn 1132 | Ser 133 | conflict |
| Ile 1133 | Val 134 | conflict |
| Ser 1164 | Gly 165 | conflict |
| Lys 1165 | Gln 166 | conflict |
| Ser 1166 | Arg 167 | conflict |
| Asn 1171 | - | insertion |
| Leu 1184 | Phe 184 | conflict |
| Met 1191 | Ile 191 | conflict |
| Leu 1195 | Val 195 | conflict |
| Met 1199 | Ile 199 | conflict |
| Phe 1200 | Tyr 200 | conflict |
| Asp 1202 | Glu 202 | conflict |
| Arg 1203 | Lys 203 | conflict |
| Lys 1205 | Gln 205 | conflict |
| Thr 1208 | - | expression tag |
| Gly 1209 | - | expression tag |
| Gly 1210 | - | expression tag |
| Leu 1211 | - | expression tag |
| Val 1212 | - | expression tag |
| Pro 1213 | - | expression tag |
| Arg 1214 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 461779.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1706.6 | |
| All* | Total formula weight | 463486.3 |
