7TNJ
Complex NNNN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Isoform Flip of Glutamate receptor 2,Voltage-dependent calcium channel gamma-3 subunit chimera | polymer | 1033 | 115444.9 | 4 | UniProt (P19491-2) UniProt (Q8VHX0) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00822) UniProt (by SIFTS) (P19491) | Rattus norvegicus (Norway rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Neuronal voltage-gated calcium channel gamma-3 subunit,Transmembrane AMPAR regulatory protein gamma-3,TARP gamma-3 |
| 2 | E, F, G, H (A, B, C, D) | CYCLOTHIAZIDE | non-polymer | 389.9 | 4 | Chemie (CYZ) PubChem (2910) PubChem (21550932) PubChem (177678892) PubChem (44582559) PubChem (657321) PubChem (52949708) PubChem (5288009) PubChem (6603794) PubChem (92143401) PubChem (92215537) PubChem (11972587) PubChem (98047042) PubChem (92142359) PubChem (98047041) PubChem (101691639) PubChem (5388988) PubChem (101691640) PubChem (131842006) |
Sequence modifications
A, B, C, D: 10 - 998 (UniProt: P19491-2)
A, B, C, D: 1004 - 1207 (UniProt: Q8VHX0)
| PDB | External Database | Details |
|---|---|---|
| Glu 241 | Asn 256 | conflict |
| Leu 382 | Val 397 | conflict |
| - | Leu 399 | deletion |
| - | Thr 400 | deletion |
| - | Glu 401 | deletion |
| - | Leu 402 | deletion |
| - | Pro 403 | deletion |
| - | Ser 404 | deletion |
| Glu 384 | Gly 405 | conflict |
| Asp 385 | Asn 406 | conflict |
| Gln 392 | Asn 413 | conflict |
| Gly 999 | - | linker |
| Thr 1000 | - | linker |
| Gly 1001 | - | linker |
| Leu 1002 | - | linker |
| Phe 1003 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Val 1007 | Ile 8 | conflict |
| Leu 1011 | Ile 12 | conflict |
| Lys 1040 | Arg 41 | conflict |
| Val 1044 | Thr 45 | conflict |
| Glu 1046 | Asp 47 | conflict |
| Asp 1047 | Asn 48 | conflict |
| Lys 1051 | Arg 52 | conflict |
| Asn 1071 | Ala 72 | conflict |
| Lys 1073 | Arg 74 | conflict |
| Leu 1075 | Val 76 | conflict |
| Gln 1078 | Lys 79 | conflict |
| Ala 1090 | Gln 91 | conflict |
| Phe 1096 | Leu 97 | conflict |
| Ile 1105 | Val 106 | conflict |
| Ile 1112 | Thr 113 | conflict |
| Met 1116 | Phe 117 | conflict |
| Ile 1121 | Val 122 | conflict |
| Tyr 1127 | His 128 | conflict |
| Lys 1128 | Arg 129 | conflict |
| Thr 1129 | Ser 130 | conflict |
| Asn 1132 | Ser 133 | conflict |
| Ile 1133 | Val 134 | conflict |
| Ser 1164 | Gly 165 | conflict |
| Lys 1165 | Gln 166 | conflict |
| Ser 1166 | Arg 167 | conflict |
| Asn 1171 | - | insertion |
| Leu 1184 | Phe 184 | conflict |
| Met 1191 | Ile 191 | conflict |
| Leu 1195 | Val 195 | conflict |
| Met 1199 | Ile 199 | conflict |
| Phe 1200 | Tyr 200 | conflict |
| Asp 1202 | Glu 202 | conflict |
| Arg 1203 | Lys 203 | conflict |
| Lys 1205 | Gln 205 | conflict |
| Thr 1208 | - | expression tag |
| Gly 1209 | - | expression tag |
| Gly 1210 | - | expression tag |
| Leu 1211 | - | expression tag |
| Val 1212 | - | expression tag |
| Pro 1213 | - | expression tag |
| Arg 1214 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 461779.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1559.5 | |
| All* | Total formula weight | 463339.2 |
