7THS
Macrocyclic plasmin inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Plasminogen | polymer | 250 | 27319.4 | 2 | UniProt (P00747) Pfam (PF00089) | Homo sapiens (human) | |
| 2 | C, H (A, B) | (6S,9R,20R,23S)-N-{[4-(aminomethyl)phenyl]methyl}-20-[(benzenesulfonyl)amino]-3,13,21-trioxo-2,6,9,14,22-pentaazatetracyclo[23.2.2.2~6,9~.2~15,18~]tritriaconta-1(27),15,17,25,28,30-hexaene-23-carboxamide | non-polymer | 809.0 | 2 | Chemie (I5Y) | |||
| 3 | D, E, F, G, I... (A, B) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 4 | L (B) | (2S)-butane-1,2-diol | non-polymer | 90.1 | 1 | Chemie (I5Q) | |||
| 5 | M, N (A, B) | water | water | 18.0 | 355 | Chemie (HOH) |
Sequence modifications
A, B: 542 - 791 (UniProt: P00747)
| PDB | External Database | Details |
|---|---|---|
| Ala 741 | Ser 760 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54638.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2380.5 | |
| All* | Total formula weight | 57019.3 |
