7TH1
Structure of Cyclophilin D Peptidyl-Prolyl Isomerase Domain bound to Macrocyclic Inhibitor B3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (X) | Peptidyl-prolyl cis-trans isomerase F, mitochondrial | polymer | 165 | 17780.3 | 1 | UniProt (P30405) Pfam (PF00160) | Homo sapiens (human) | PPIase F,Cyclophilin D,CyP-D,CypD,Cyclophilin F,Mitochondrial cyclophilin,CyP-M,Rotamase F |
| 2 | B (X) | (4S,7S,11R,13E,19S)-N-[2-(2-aminoethoxy)ethyl]-7-benzyl-4-[(3-methylphenyl)methyl]-3,6,12,15,21-pentaoxo-1,3,4,5,6,7,8,9,10,12,15,16,17,18,19,20,21,22-octadecahydro-2H-7,11-methano-2,5,11,16,20-benzopentaazacyclotetracosine-19-carboxamide | non-polymer | 794.0 | 1 | Chemie (I5J) | |||
| 3 | C (X) | water | water | 18.0 | 191 | Chemie (HOH) |
Sequence modifications
X: 3 - 165 (UniProt: P30405)
| PDB | External Database | Details |
|---|---|---|
| Asn 1 | - | expression tag |
| Ala 2 | - | expression tag |
| Ile 133 | Lys 175 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17780.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 794.0 | |
| All* | Total formula weight | 18574.2 |
