7TEU
Crystal structure of JAK2 JH1 with type II inhibitor YLIU-04-105-1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase JAK2 | polymer | 317 | 37090.3 | 1 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (human) | Janus kinase 2,JAK-2 |
2 | A | 3-{(4S)-2-[(cyclopropanecarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}-N-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}-4-methylbenzamide | non-polymer | 605.7 | 1 | Chemie (I6C) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | water | water | 18.0 | 200 | Chemie (HOH) |
Sequence modifications
A: 837 - 1132 (UniProt: O60674)
PDB | External Database | Details |
---|---|---|
Met 816 | - | initiating methionine |
Gly 817 | - | expression tag |
Ser 818 | - | expression tag |
Ser 819 | - | expression tag |
His 820 | - | expression tag |
His 821 | - | expression tag |
His 822 | - | expression tag |
His 823 | - | expression tag |
His 824 | - | expression tag |
His 825 | - | expression tag |
Ser 826 | - | expression tag |
Ser 827 | - | expression tag |
Gly 828 | - | expression tag |
Leu 829 | - | expression tag |
Val 830 | - | expression tag |
Pro 831 | - | expression tag |
Arg 832 | - | expression tag |
Gly 833 | - | expression tag |
Ser 834 | - | expression tag |
His 835 | - | expression tag |
Met 836 | - | expression tag |
Phe 1007 | Tyr 1007 | engineered mutation |
Phe 1008 | Tyr 1008 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37090.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 697.7 | |
All* | Total formula weight | 37788.1 |