7TES
Cryo-EM structure of GluN1b-2B NMDAR in complex with Fab5 in Non-active1 conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Glutamate receptor ionotropic, NMDA 1 | polymer | 862 | 96944.9 | 2 | UniProt (P35439) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB | Rattus norvegicus (Norway rat) | GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1 |
| 2 | B, D | Glutamate receptor ionotropic, NMDA 2B | polymer | 883 | 98797.8 | 2 | UniProt (Q00960) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB | Rattus norvegicus (Norway rat) | GluN2B,Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,NMDAR2B,NR2B |
| 3 | H, M | Fab5 heavy chain | polymer | 221 | 23844.7 | 2 | Mus musculus (Mouse) | ||
| 4 | L, N | Fab5 light chain | polymer | 215 | 23855.3 | 2 | Mus musculus (Mouse) |
Sequence modifications
A, C: 1 - 859 (UniProt: P35439)
B, D: 27 - 852 (UniProt: Q00960)
| PDB | External Database | Details |
|---|---|---|
| Ser 22 | Cys 22 | conflict |
| Gln 61 | Asn 61 | conflict |
| Asp 260 | Asn 260 | conflict |
| Gln 371 | Asn 371 | conflict |
| Gln 492 | Asn 492 | conflict |
| Gln 512 | Asn 512 | conflict |
| Gln 615 | Glu 615 | conflict |
| Ser 616 | Glu 616 | conflict |
| Ser 618 | Glu 618 | conflict |
| Thr 619 | Glu 619 | conflict |
| Gln 792 | Asn 792 | conflict |
| Cys 831 | Phe 831 | conflict |
| Ser 860 | - | expression tag |
| Arg 861 | - | expression tag |
| Ala 862 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -30 | - | expression tag |
| Gly -29 | - | expression tag |
| Thr -28 | - | expression tag |
| Met -27 | - | expression tag |
| Arg -26 | - | expression tag |
| Leu -25 | - | expression tag |
| Phe -24 | - | expression tag |
| Leu -23 | - | expression tag |
| Leu -22 | - | expression tag |
| Ala -21 | - | expression tag |
| Val -20 | - | expression tag |
| Leu -19 | - | expression tag |
| Phe -18 | - | expression tag |
| Leu -17 | - | expression tag |
| Phe -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Phe -14 | - | expression tag |
| Ala -13 | - | expression tag |
| Arg -12 | - | expression tag |
| Ala -11 | - | expression tag |
| Thr -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Trp -8 | - | expression tag |
| Ser -7 | - | expression tag |
| His -6 | - | expression tag |
| Pro -5 | - | expression tag |
| Gln -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Glu -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Gly 4 | - | expression tag |
| Gly 5 | - | expression tag |
| Gly 6 | - | expression tag |
| Ser 7 | - | expression tag |
| Gly 8 | - | expression tag |
| Gly 9 | - | expression tag |
| Ser 10 | - | expression tag |
| Ala 11 | - | expression tag |
| Trp 12 | - | expression tag |
| Ser 13 | - | expression tag |
| His 14 | - | expression tag |
| Pro 15 | - | expression tag |
| Gln 16 | - | expression tag |
| Phe 17 | - | expression tag |
| Glu 18 | - | expression tag |
| Lys 19 | - | expression tag |
| Gly 20 | - | expression tag |
| Ala 21 | - | expression tag |
| Leu 22 | - | expression tag |
| Val 23 | - | expression tag |
| Pro 24 | - | expression tag |
| Arg 25 | - | expression tag |
| Gly 26 | - | expression tag |
| Asp 348 | Asn 348 | conflict |
| Cys 557 | Asp 557 | conflict |
| Ser 588 | Cys 588 | conflict |
| Val 600 | Phe 600 | conflict |
| Ser 838 | Cys 838 | conflict |
| Ser 849 | Cys 849 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 486885.3 | |
| All* | Total formula weight | 486885.3 |
