7TCN
Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.SOSIP.664 with high-mannose glycans
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, E, I | Envelope glycoprotein gp160 | polymer | 486 | 54456.4 | 3 | UniProt (M4M0W3) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
2 | B, F, J | Glycoprotein 41 | polymer | 160 | 18146.7 | 3 | UniProt (Q2N0S5) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 | Transmembrane protein gp41, TM, gp41 |
3 | C, G, K | CH235.12 Fab Heavy Chain | polymer | 225 | 24319.4 | 3 | Homo sapiens (Human) | ||
4 | D, H, L | CH235.12 Fab Light Chain | polymer | 213 | 23451.0 | 3 | Homo sapiens (Human) | ||
5 | 0, M, N, e, j... | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 6 | In PDB GlyTouCan (G15407YE) | |||
6 | 4, R, n | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
7 | h, y | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
8 | A, E, I | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 13 | Chemie (NAG) | |||
9 | C, G, K | alpha-D-mannopyranose | non-polymer | 180.2 | 3 | Chemie (MAN) |
Sequence modifications
A, E, I: 35 - 503 (UniProt: M4M0W3)
B, F, J: 511 - 664 (UniProt: Q2N0S5)
PDB | External Database | Details |
---|---|---|
Met 7 | - | initiating methionine |
Pro 8 | - | expression tag |
Met 9 | - | expression tag |
Gly 10 | - | expression tag |
Ser 11 | - | expression tag |
Leu 12 | - | expression tag |
Gln 13 | - | expression tag |
Pro 14 | - | expression tag |
Leu 15 | - | expression tag |
Ala 16 | - | expression tag |
Thr 17 | - | expression tag |
Leu 18 | - | expression tag |
Tyr 19 | - | expression tag |
Leu 20 | - | expression tag |
Leu 21 | - | expression tag |
Gly 22 | - | expression tag |
Met 23 | - | expression tag |
Leu 24 | - | expression tag |
Val 25 | - | expression tag |
Ala 26 | - | expression tag |
Ser 27 | - | expression tag |
Val 28 | - | expression tag |
Leu 29 | - | expression tag |
Ala 30 | - | expression tag |
Ala 31 | - | expression tag |
Glu 32 | - | expression tag |
Asn 33 | - | expression tag |
Leu 34 | - | expression tag |
Lys 64 | Glu 60 | conflict |
Trp 316 | Ala 301 | conflict |
Lys 488 | Glu 473 | conflict |
Ile 489 | Val 474 | conflict |
Glu 490 | Lys 475 | conflict |
Arg 498 | Asn 483 | conflict |
Cys 499 | Ala 484 | conflict |
Lys 500 | Arg 485 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 505 | - | expression tag |
Arg 506 | - | expression tag |
Arg 507 | - | expression tag |
Arg 508 | - | expression tag |
Arg 509 | - | expression tag |
Arg 510 | - | expression tag |
Pro 559 | Ile 556 | conflict |
Cys 605 | Thr 602 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 361120.3 | |
Branched | Number of molecules | 11 |
Total formula weight | 6614.1 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 3416.2 | |
All* | Total formula weight | 371150.5 |