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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7TCC

Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibodies A19-46.1 and B1-182.1

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C
(A, B, C)		Spike glycoproteinpolymer1272141111.23UniProt (P0DTC2)
Pfam (PF16451)
Pfam (PF09408)
Pfam (PF19209)
Pfam (PF01601)		Severe acute respiratory syndrome coronavirus 2S glycoprotein,E2,Peplomer protein
2D, H, J
(D, H, M)		Heavy chain of antibody A19-46.1polymer12614057.73Homo sapiens
3E, I, K
(E, L, N)		Light chain of antibody A19-46.1polymer11011473.73Homo sapiens
4F, L, N
(J, O, F)		heavy chain of antibody B1-182.1polymer12313473.13Homo sapiens
5G, M, O
(K, P, G)		Light chain of antibody B1-182.1polymer10811776.03Homo sapiens
6AA, BA, P, Q, R...
(a, b, I, Q, R...)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.413In PDB
GlyTouCan (G42666HT)
7CA, DA, EA, FA, GA...
(A, B, C)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.215Chemie (NAG)
Sequence modifications
A, B, C: 14 - 1205 (UniProt: P0DTC2)
PDBExternal DatabaseDetails
Val 67Ala 67conflict
-His 69deletion
-Val 70deletion
Ile 95Thr 95conflict
-Gly 142deletion
-Val 143deletion
-Tyr 144deletion
Asp 142Tyr 145conflict
Ile 212-insertion
Val 213-insertion
Arg 214Asn 211conflict
Glu 214Leu 212conflict
Pro 214Val 213conflict
Glu 214Arg 214conflict
Asp 339Gly 339conflict
Leu 371Ser 371conflict
Pro 373Ser 373conflict
Phe 375Ser 375conflict
Asn 417Lys 417conflict
Lys 440Asn 440conflict
Ser 446Gly 446conflict
Asn 477Ser 477conflict
Lys 478Thr 478conflict
Ala 484Glu 484conflict
Arg 493Gln 493conflict
Ser 496Gly 496conflict
Arg 498Gln 498conflict
Tyr 501Asn 501conflict
His 505Tyr 505conflict
Lys 547Thr 547conflict
Gly 614Asp 614conflict
Tyr 655His 655conflict
Lys 679Asn 679conflict
His 681Pro 681conflict
Gly 682Arg 682conflict
Ser 683Arg 683conflict
Ser 685Arg 685conflict
Lys 764Asn 764conflict
Tyr 796Asp 796conflict
Lys 856Asn 856conflict
His 954Gln 954conflict
Lys 969Asn 969conflict
Phe 981Leu 981conflict
Pro 986Lys 986conflict
Pro 987Val 987conflict
Tyr 1206-expression tag
Glu 1207-expression tag
Gln 1208-expression tag
Gly 1209-expression tag
Ser 1210-expression tag
Gly 1211-expression tag
Tyr 1212-expression tag
Ile 1213-expression tag
Pro 1214-expression tag
Glu 1215-expression tag
Ala 1216-expression tag
Pro 1217-expression tag
Arg 1218-expression tag
Asp 1219-expression tag
Gly 1220-expression tag
Gln 1221-expression tag
Ala 1222-expression tag
Tyr 1223-expression tag
Val 1224-expression tag
Arg 1225-expression tag
Lys 1226-expression tag
Asp 1227-expression tag
Gly 1228-expression tag
Glu 1229-expression tag
Trp 1230-expression tag
Val 1231-expression tag
Leu 1232-expression tag
Leu 1233-expression tag
Ser 1234-expression tag
Thr 1235-expression tag
Phe 1236-expression tag
Leu 1237-expression tag
Gly 1238-expression tag
Arg 1239-expression tag
Ser 1240-expression tag
Leu 1241-expression tag
Glu 1242-expression tag
Val 1243-expression tag
Leu 1244-expression tag
Phe 1245-expression tag
Gln 1246-expression tag
Gly 1247-expression tag
Pro 1248-expression tag
Gly 1249-expression tag
His 1250-expression tag
His 1251-expression tag
His 1252-expression tag
His 1253-expression tag
His 1254-expression tag
His 1255-expression tag
His 1256-expression tag
His 1257-expression tag
Ser 1258-expression tag
Ala 1259-expression tag
Trp 1260-expression tag
Ser 1261-expression tag
His 1262-expression tag
Pro 1263-expression tag
Gln 1264-expression tag
Phe 1265-expression tag
Glu 1266-expression tag
Lys 1267-expression tag
Gly 1268-expression tag
Gly 1269-expression tag
Gly 1270-expression tag
Ser 1271-expression tag
Gly 1272-expression tag
Gly 1273-expression tag
Gly 1274-expression tag
Gly 1275-expression tag
Ser 1276-expression tag
Gly 1277-expression tag
Gly 1278-expression tag
Ser 1279-expression tag
Ala 1280-expression tag
Trp 1281-expression tag
Ser 1282-expression tag
His 1283-expression tag
Pro 1284-expression tag
Gln 1285-expression tag
Phe 1286-expression tag
Glu 1287-expression tag
Lys 1288-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains15
Total formula weight575675.2
BranchedNumber of molecules13
Total formula weight5517.2
Non-Polymers*Number of molecules15
Total formula weight3318.1
All*Total formula weight584510.6
*Water molecules are not included.

226707

PDB entries from 2024-10-30

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