7TBW

The structure of ATP-bound ABCA1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	ATP-binding cassette, sub-family A (ABC1), member 1	polymer	2270	255653.0	1	UniProt (B2RUU2) Pfam (PF12698) Pfam (PF00005) UniProt (by SIFTS) (O95477)	Homo sapiens (human)
2	B (B)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
3	C (C)	beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G89225LT)
4	D (A)	CHOLESTEROL	non-polymer		386.7	1	Chemie (CLR)
5	E, F (A)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
6	G, H (A)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
7	I, J (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

A: 1 - 2261 (UniProt: B2RUU2)

PDB	External Database	Details
Gln 1058	Glu 1058	engineered mutation
Gln 2070	Glu 2070	engineered mutation
Gly 2262	-	expression tag
Asp 2263	-	expression tag
Tyr 2264	-	expression tag
Lys 2265	-	expression tag
Asp 2266	-	expression tag
Asp 2267	-	expression tag
Asp 2268	-	expression tag
Asp 2269	-	expression tag
Lys 2270	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	255653.0
Branched	Number of molecules	2
	Total formula weight	1335.2
Non-Polymers*	Number of molecules	7
	Total formula weight	1892.0
All*	Total formula weight	258880.3

*Water molecules are not included.