7TBC

Crystal structure of Plasmepsin X from Plasmodium falciparum in complex with WM382

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Plasmepsin 10	polymer	377	42948.5	1	UniProt (Q2KNW6) Pfam (PF00026) UniProt (by SIFTS) (Q8IAS0)	Plasmodium falciparum (malaria parasite P. falciparum)
2	B, E, F, G, H... (A)	1,2-ETHANEDIOL	non-polymer		62.1	15	Chemie (EDO)
3	C (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
4	D (A)	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
5	S (A)	(4R)-4-[(2E)-4,4-diethyl-2-imino-6-oxo-1,3-diazinan-1-yl]-N-[(4S)-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]-3,4-dihydro-2H-1-benzopyran-6-carboxamide	non-polymer		504.6	1	Chemie (I0L)
6	T (A)	water	water		18.0	9	Chemie (HOH)

Sequence modifications

A: 212 - 573 (UniProt: Q2KNW6)

PDB	External Database	Details
Glu 574	-	expression tag
Asn 575	-	expression tag
Leu 576	-	expression tag
Tyr 577	-	expression tag
Phe 578	-	expression tag
Gln 579	-	expression tag
Gly 580	-	expression tag
His 581	-	expression tag
His 582	-	expression tag
His 583	-	expression tag
His 584	-	expression tag
His 585	-	expression tag
His 586	-	expression tag
His 587	-	expression tag
His 588	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42948.5
Non-Polymers*	Number of molecules	18
	Total formula weight	1851.1
All*	Total formula weight	44799.6

*Water molecules are not included.