7TB8
Cryo-EM structure of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Spike glycoprotein | polymer | 1195 | 132306.4 | 3 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB | Severe acute respiratory syndrome coronavirus 2 | S glycoprotein,E2,Peplomer protein |
| 2 | D, F, J | The heavy chain of SARS-CoV-2 antibody A19-61.1 | polymer | 127 | 13934.4 | 3 | Homo sapiens | ||
| 3 | E, G, K | The light chain of SARS-COV-2 antibody A19-61.1 | polymer | 107 | 11571.9 | 3 | Homo sapiens | ||
| 4 | H | The heavy chain of SARS-CoV-2 antiboddy antibody B1-182.1 | polymer | 123 | 13473.1 | 1 | Homo sapiens | ||
| 5 | L | The light chain of SARS-COV-2 antibody B1-182.1 | polymer | 108 | 11776.0 | 1 | Homo sapiens | ||
| 6 | I, N, O, P, Q... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 8 | In PDB GlyTouCan (G42666HT) | |||
| 7 | M | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G79924RM) | |||
| 8 | A, B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 25 | Chemie (NAG) |
Sequence modifications
A, B, C: 14 - 1208 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Gly 682 | Arg 682 | conflict |
| Ser 683 | Arg 683 | conflict |
| Ser 685 | Arg 685 | conflict |
| Pro 986 | Lys 986 | conflict |
| Pro 987 | Val 987 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 498687.3 | |
| Branched | Number of molecules | 9 |
| Total formula weight | 3819.6 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 5530.2 | |
| All* | Total formula weight | 508037.1 |
