7TB8

Cryo-EM structure of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Spike glycoprotein	polymer	1195	132306.4	3	UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601)	Severe acute respiratory syndrome coronavirus 2	S glycoprotein,E2,Peplomer protein
2	D, F, J (D, F, J)	The heavy chain of SARS-CoV-2 antibody A19-61.1	polymer	127	13934.4	3		Homo sapiens
3	E, G, K (E, G, K)	The light chain of SARS-COV-2 antibody A19-61.1	polymer	107	11571.9	3		Homo sapiens
4	H (H)	The heavy chain of SARS-CoV-2 antiboddy antibody B1-182.1	polymer	123	13473.1	1		Homo sapiens
5	I (L)	The light chain of SARS-COV-2 antibody B1-182.1	polymer	108	11776.0	1		Homo sapiens
6	L, N, O, P, Q... (I, N, O, P, Q...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	8	In PDB GlyTouCan (G42666HT)
7	M (M)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G79924RM)
8	AA, BA, CA, DA, EA... (A, B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	25	Chemie (NAG)

Sequence modifications

A, B, C: 14 - 1208 (UniProt: P0DTC2)

PDB	External Database	Details
Gly 682	Arg 682	conflict
Ser 683	Arg 683	conflict
Ser 685	Arg 685	conflict
Pro 986	Lys 986	conflict
Pro 987	Val 987	conflict

Contents of the asymmetric unit

Polymers	Number of chains	11
	Total formula weight	498687.3
Branched	Number of molecules	9
	Total formula weight	3819.6
Non-Polymers*	Number of molecules	25
	Total formula weight	5530.2
All*	Total formula weight	508037.1

*Water molecules are not included.