7TB4
Cryo-EM structure of the spike of SARS-CoV-2 Omicron variant of concern
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Surface glycoprotein | polymer | 1192 | 132465.1 | 3 | UniProt (A0A8A4XEV3) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) UniProt (by SIFTS) (P0DTC2) | Severe acute respiratory syndrome coronavirus 2 | |
| 2 | D, E, F, G, H... (D, E, F, G, H...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 15 | In PDB GlyTouCan (G42666HT) | |||
| 3 | AA, BA, CA, DA, EA... (A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 29 | Chemie (NAG) |
Sequence modifications
A, B, C: 14 - 1208 (UniProt: A0A8A4XEV3)
| PDB | External Database | Details |
|---|---|---|
| Val 67 | Ala 67 | conflict |
| - | His 69 | deletion |
| - | Val 70 | deletion |
| Ile 95 | Thr 95 | conflict |
| - | Asn 208 | deletion |
| Ile 212 | Leu 209 | conflict |
| Glu 214 | - | insertion |
| Pro 214 | - | insertion |
| Glu 214 | - | insertion |
| Asp 339 | Gly 336 | conflict |
| Leu 371 | Ser 368 | conflict |
| Pro 373 | Ser 370 | conflict |
| Phe 375 | Ser 372 | conflict |
| Asn 417 | Lys 414 | conflict |
| Lys 440 | Asn 437 | conflict |
| Ser 446 | Gly 443 | conflict |
| Asn 477 | Ser 474 | conflict |
| Lys 478 | Thr 475 | conflict |
| Ala 484 | Arg 481 | conflict |
| Arg 493 | Gln 490 | conflict |
| Ser 496 | Gly 493 | conflict |
| Arg 498 | Gln 495 | conflict |
| Tyr 501 | Asn 498 | conflict |
| His 505 | Tyr 502 | conflict |
| Lys 547 | Thr 544 | conflict |
| Tyr 655 | His 652 | conflict |
| Lys 679 | Asn 676 | conflict |
| His 681 | Pro 678 | conflict |
| Gly 682 | Arg 679 | conflict |
| Ser 683 | Arg 680 | conflict |
| Ser 685 | Arg 682 | conflict |
| Lys 764 | Asn 761 | conflict |
| Tyr 796 | Asp 793 | conflict |
| Lys 856 | Asn 853 | conflict |
| His 954 | Gln 951 | conflict |
| Lys 969 | Asn 966 | conflict |
| Phe 981 | Leu 978 | conflict |
| Pro 986 | Lys 983 | conflict |
| Pro 987 | Val 984 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 397395.3 | |
| Branched | Number of molecules | 15 |
| Total formula weight | 6366.0 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 6415.0 | |
| All* | Total formula weight | 410176.3 |
