7TAO

Cryo-EM structure of bafilomycin A1 bound to yeast VO V-ATPase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	D	V-type proton ATPase subunit c'	polymer	164	17046.4	1	UniProt (P32842) Pfam (PF00137) In PDB	Saccharomyces cerevisiae (baker's yeast)	V-ATPase subunit c',Proteolipid protein VMA11,Trifluoperazine resistance protein 3,V-ATPase 16 kDa proteolipid subunit 2,Vacuolar proton pump c' subunit
2	C	V-type proton ATPase subunit c''	polymer	213	22610.6	1	UniProt (P23968) Pfam (PF00137) In PDB	Saccharomyces cerevisiae (baker's yeast)	V-ATPase subunit c'',V-ATPase 22 kDa proteolipid subunit,Vacuolar proton pump c'' subunit
3	N	V0 assembly protein 1	polymer	265	29694.9	1	UniProt (P53262) Pfam (PF20520) In PDB	Saccharomyces cerevisiae (baker's yeast)
4	M	V-type proton ATPase subunit e	polymer	73	8387.1	1	UniProt (Q3E7B6) Pfam (PF05493) In PDB	Saccharomyces cerevisiae (baker's yeast)	V-ATPase subunit e,Low dye-binding protein 10,Vacuolar proton pump subunit e
5	E, F, G, H, I...	V-type proton ATPase subunit c	polymer	160	16357.5	8	UniProt (P25515) Pfam (PF00137) In PDB	Saccharomyces cerevisiae (baker's yeast)	V-ATPase subunit c,Guanine nucleotide exchange factor 2,V-ATPase 16 kDa proteolipid subunit 1,Vacuolar proton pump c subunit
6	O	Yeast V-ATPase subunit f	polymer	85	9369.9	1	UniProt (P0C5R9) In PDB	Saccharomyces cerevisiae (baker's yeast)
7	B	V-type proton ATPase subunit d	polymer	345	39822.5	1	UniProt (P32366) Pfam (PF01992) In PDB	Saccharomyces cerevisiae (baker's yeast)	V-ATPase subunit d,V-ATPase 39 kDa subunit,V-ATPase subunit M39,Vacuolar proton pump subunit d
8	A	V-type proton ATPase subunit a, vacuolar isoform	polymer	840	95625.5	1	UniProt (P32563) Pfam (PF01496) In PDB	Saccharomyces cerevisiae (baker's yeast)	V-ATPase a 1 subunit,V-ATPase 95 kDa subunit,Vacuolar pH protein 1,Vacuolar proton pump a subunit,Vacuolar proton translocating ATPase subunit a 1
9	D, E, F, G, H...	(5R)-2,4-dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S,4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl}-4-methyl-5-propan-2-yl-alpha-D-threo-pentopyranose	non-polymer		622.8	9	Chemie (WEV)

Contents of the asymmetric unit

Polymers	Number of chains	15
	Total formula weight	353416.9
Non-Polymers*	Number of molecules	9
	Total formula weight	5605.5
All*	Total formula weight	359022.3

*Water molecules are not included.