7TAO

Cryo-EM structure of bafilomycin A1 bound to yeast VO V-ATPase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (D)	V-type proton ATPase subunit c'	polymer	164	17046.4	1	UniProt (P32842) Pfam (PF00137)	Saccharomyces cerevisiae (baker's yeast)	V-ATPase subunit c',Proteolipid protein VMA11,Trifluoperazine resistance protein 3,V-ATPase 16 kDa proteolipid subunit 2,Vacuolar proton pump c' subunit
2	B (C)	V-type proton ATPase subunit c''	polymer	213	22610.6	1	UniProt (P23968) Pfam (PF00137)	Saccharomyces cerevisiae (baker's yeast)	V-ATPase subunit c'',V-ATPase 22 kDa proteolipid subunit,Vacuolar proton pump c'' subunit
3	C (N)	V0 assembly protein 1	polymer	265	29694.9	1	UniProt (P53262) Pfam (PF20520)	Saccharomyces cerevisiae (baker's yeast)
4	D (M)	V-type proton ATPase subunit e	polymer	73	8387.1	1	UniProt (Q3E7B6) Pfam (PF05493)	Saccharomyces cerevisiae (baker's yeast)	V-ATPase subunit e,Low dye-binding protein 10,Vacuolar proton pump subunit e
5	E, G, H, I, J... (E, F, G, H, I...)	V-type proton ATPase subunit c	polymer	160	16357.5	8	UniProt (P25515) Pfam (PF00137)	Saccharomyces cerevisiae (baker's yeast)	V-ATPase subunit c,Guanine nucleotide exchange factor 2,V-ATPase 16 kDa proteolipid subunit 1,Vacuolar proton pump c subunit
6	F (O)	Yeast V-ATPase subunit f	polymer	85	9369.9	1	UniProt (P0C5R9) Pfam (PF23489)	Saccharomyces cerevisiae (baker's yeast)
7	N (B)	V-type proton ATPase subunit d	polymer	345	39822.5	1	UniProt (P32366) Pfam (PF01992)	Saccharomyces cerevisiae (baker's yeast)	V-ATPase subunit d,V-ATPase 39 kDa subunit,V-ATPase subunit M39,Vacuolar proton pump subunit d
8	O (A)	V-type proton ATPase subunit a, vacuolar isoform	polymer	840	95625.5	1	UniProt (P32563) Pfam (PF01496)	Saccharomyces cerevisiae (baker's yeast)	V-ATPase a 1 subunit,V-ATPase 95 kDa subunit,Vacuolar pH protein 1,Vacuolar proton pump a subunit,Vacuolar proton translocating ATPase subunit a 1
9	P, Q, R, S, T... (D, E, F, G, H...)	(5R)-2,4-dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S,4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl}-4-methyl-5-propan-2-yl-alpha-D-threo-pentopyranose	non-polymer		622.8	9	Chemie (WEV) PubChem (16759598) PubChem (16760033) PubChem (2287) PubChem (22524674) PubChem (24812816) PubChem (16760308) PubChem (44634695) PubChem (72947) PubChem (21159502) PubChem (23975129) PubChem (24870922) PubChem (52947790) PubChem (44119935) PubChem (71299752) PubChem (53321987) PubChem (73265348) PubChem (57792665) PubChem (59866780) PubChem (71046195) PubChem (71308159) PubChem (71668406) PubChem (73951098) PubChem (90479784) PubChem (90656913) PubChem (91333159) PubChem (94232247) PubChem (99719282) PubChem (99719280) PubChem (5353429) PubChem (5385089) PubChem (117059119) PubChem (5458921) PubChem (5702538) PubChem (6375210) PubChem (6436223) PubChem (122361934) PubChem (124081954) PubChem (124490403) PubChem (125040765) PubChem (131863036) PubChem (6610280) PubChem (99719281) PubChem (9960729) PubChem (9986395) PubChem (137521726) PubChem (138404419) PubChem (11039423) PubChem (139211178) PubChem (13375088) PubChem (124524084) PubChem (11467721) PubChem (125040764) PubChem (125040766) PubChem (125040767) PubChem (155817677) PubChem (155971306) PubChem (162981175) PubChem (125182885) PubChem (166632465) PubChem (166639048) PubChem (170922383) PubChem (129012189) PubChem (133126837) PubChem (133268469) PubChem (134694634) PubChem (135601084) PubChem (138107052) PubChem (138756148) PubChem (146018879) PubChem (162981170) PubChem (162981171) PubChem (162981172) PubChem (162981173) PubChem (162981174) PubChem (162981176) PubChem (166640169) PubChem (170999728)

Contents of the asymmetric unit

Polymers	Number of chains	15
	Total formula weight	353416.9
Non-Polymers*	Number of molecules	9
	Total formula weight	5605.5
All*	Total formula weight	359022.3

*Water molecules are not included.