7T9Y

Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 8/9

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	3C-like proteinase	polymer	306	33793.5	2	UniProt (P0DTD1) Pfam (PF05409) In PDB	Severe acute respiratory syndrome coronavirus 2	3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase
2	C, D	Nonstructural protein 8/9	polymer	10	1116.2	2	UniProt (by SIFTS) (P0DTD1) In PDB	Severe acute respiratory syndrome coronavirus 2
3	A, B	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
4		water	water		18.0	435	Chemie (HOH)

Sequence modifications

A, B: 1 - 306 (UniProt: P0DTD1)

PDB	External Database	Details
Ala 145	Cys 3408	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	69819.5
Non-Polymers*	Number of molecules	2
	Total formula weight	184.2
All*	Total formula weight	70003.6

*Water molecules are not included.