7T9U
Crystal structure of hSTING with an agonist (SHR169224)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Stimulator of interferon genes protein | polymer | 198 | 22603.4 | 1 | UniProt (Q86WV6) Pfam (PF15009) | Homo sapiens (human) | hSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,hMITA,Transmembrane protein 173 |
| 2 | B (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) PubChem (271) | |||
| 3 | C (A) | (3S,4S)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4-(prop-2-en-1-yl)-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide | non-polymer | 394.4 | 1 | Chemie (GD2) PubChem (147570332) | |||
| 4 | D (A) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 149 - 345 (UniProt: Q86WV6)
| PDB | External Database | Details |
|---|---|---|
| Met 148 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 22603.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 434.5 | |
| All* | Total formula weight | 23037.9 |
