7T7H

Crystal structure of Vaccinia Virus decapping enzyme D9 in complex with inhibitor CP100356

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	DNA repair NTP-phosphohydrolase	polymer	221	26102.1	2	UniProt (L7QJE0) Pfam (PF00293) UniProt (by SIFTS) (P04311) In PDB	Vaccinia virus Western Reserve	MutT motif/mRNA decapping enzyme,NTP-phosphohydrolase,Putative D9R
2	A	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
3	A, B	4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxyquinazolin-2-amine	non-polymer		560.6	2	Chemie (G7R)
4		water	water		18.0	194	Chemie (HOH)

Sequence modifications

A, B: 1 - 213 (UniProt: L7QJE0)

PDB	External Database	Details
Leu 214	-	expression tag
Glu 215	-	expression tag
His 216	-	expression tag
His 217	-	expression tag
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag
His 221	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	52204.2
Non-Polymers*	Number of molecules	4
	Total formula weight	1167.3
All*	Total formula weight	53371.4

*Water molecules are not included.