7T70
Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 4/5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 3C-like proteinase | polymer | 306 | 33793.5 | 2 | UniProt (P0DTD1) Pfam (PF05409) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | 3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase |
| 2 | C, D (C, D) | Nonstructural protein 4/5 | polymer | 12 | 1326.6 | 2 | UniProt (by SIFTS) (P0DTD1) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | |
| 3 | BA, CA, E, F, FA... (B, A, C, D) | GLYCEROL | non-polymer | 92.1 | 18 | Chemie (GOL) | |||
| 4 | AA, DA, EA, G, H... (B, A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 14 | Chemie (DMS) | |||
| 5 | KA, LA, MA, NA (A, B, C, D) | water | water | 18.0 | 364 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 306 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ala 145 | Cys 3408 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 70240.1 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 2751.6 | |
| All* | Total formula weight | 72991.6 |
