7T4G

The Envelope Glycoprotein SIVmac239.K180S SOSIP trimer in complex with 3 copies of the neutralizing antibody K11

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, I (A, C, E)	Envelope glycoprotein gp120	polymer	527	60324.4	3	UniProt (A0A5C0E975) Pfam (PF00516) UniProt (by SIFTS) (Q5QG95)	Simian immunodeficiency virus
2	B, F, J (B, D, F)	Envelope glycoprotein gp41	polymer	159	18144.6	3	UniProt (L7XFX7) Pfam (PF00517) UniProt (by SIFTS) (Q5QG95)	Simian immunodeficiency virus
3	C, G, K (H, G, J)	K11 IgG heavy chain	polymer	485	53290.8	3		Macaca mulatta
4	D, H, L (L, I, K)	K11 IgG light chain	polymer	232	25293.2	3		Macaca mulatta
5	M, MA, Z (M, m, Z)	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1397.2	3	In PDB GlyTouCan (G34499SX)
6	AA, HA, KA, LA, N... (a, h, k, l, N...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	11	In PDB GlyTouCan (G42666HT)
7	BA, CA, DA, IA, O... (b, c, d, i, O...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	12	In PDB GlyTouCan (G21290RB)
8	EA, R, RA (e, R, r)	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1235.1	3	In PDB GlyTouCan (G46836GH)
9	S, SA (S, s)	alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB GlyTouCan (G22573RC)
10	GA, JA, T, W, YA (g, j, T, W, y)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	5	In PDB GlyTouCan (G15407YE)
11	FA (f)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
12	TA, WA (t, w)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB GlyTouCan (G81315DD)
13	AB, AC, BB, BC, CB... (A, E, F, B, C...)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	36	Chemie (NAG)

Sequence modifications

A, C, E: 1 - 525 (UniProt: A0A5C0E975)

PDB	External Database	Details
Ser 180	Lys 180	engineered mutation
Ser 511	Asp 511	conflict
Cys 512	Val 512	conflict
Arg 523	Asn 523	conflict
Arg 526	-	expression tag
Arg 527	-	expression tag

B, D, F: 528 - 675 (UniProt: L7XFX7)

PDB	External Database	Details
Pro 574	Val 561	conflict
Cys 620	His 607	conflict
Gly 676	-	expression tag
Ser 677	-	expression tag
Gly 678	-	expression tag
His 679	-	expression tag
His 680	-	expression tag
His 681	-	expression tag
His 682	-	expression tag
His 683	-	expression tag
His 684	-	expression tag
His 685	-	expression tag
His 686	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	471158.9
Branched	Number of molecules	39
	Total formula weight	26250.2
Non-Polymers*	Number of molecules	36
	Total formula weight	7963.5
All*	Total formula weight	505372.6

*Water molecules are not included.