7T3C
GATOR1-RAG-RAGULATOR - Dual Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | GATOR complex protein NPRL2 | polymer | 380 | 43711.4 | 1 | UniProt (Q8WTW4) Pfam (PF06218) | Homo sapiens (human) | Gene 21 protein,G21 protein,Nitrogen permease regulator 2-like protein,NPR2-like protein,Tumor suppressor candidate 4 |
| 2 | B (A) | GATOR complex protein DEPDC5 | polymer | 1603 | 181478.0 | 1 | UniProt (O75140) Pfam (PF23013) Pfam (PF12257) Pfam (PF00610) Pfam (PF19418) | Homo sapiens (human) | DEP domain-containing protein 5 |
| 3 | C, K (H, O) | Ragulator complex protein LAMTOR3 | polymer | 124 | 13637.7 | 2 | UniProt (Q9UHA4) Pfam (PF08923) | Homo sapiens (human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MEK-binding partner 1,Mp1,Mitogen-activated protein kinase kinase 1-interacting protein 1,Mitogen-activated protein kinase scaffold protein 1 |
| 4 | D, L (G, N) | Ragulator complex protein LAMTOR2 | polymer | 125 | 13517.5 | 2 | UniProt (Q9Y2Q5) Pfam (PF03259) | Homo sapiens (human) | Endosomal adaptor protein p14,Late endosomal/lysosomal Mp1-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2,Mitogen-activated protein-binding protein-interacting protein,MAPBP-interacting protein,Roadblock domain-containing protein 3 |
| 5 | E, M (J, Q) | Ragulator complex protein LAMTOR5 | polymer | 91 | 9622.9 | 2 | UniProt (O43504) Pfam (PF16672) | Homo sapiens (human) | Hepatitis B virus X-interacting protein,HBX-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 |
| 6 | F, N (I, P) | Ragulator complex protein LAMTOR4 | polymer | 99 | 10753.2 | 2 | UniProt (Q0VGL1) | Homo sapiens (human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4 |
| 7 | G, O (F, M) | Ragulator complex protein LAMTOR1 | polymer | 161 | 17762.8 | 2 | UniProt (Q6IAA8) Pfam (PF15454) | Homo sapiens (human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1,Lipid raft adaptor protein p18,Protein associated with DRMs and endosomes,p27Kip1-releasing factor from RhoA,p27RF-Rho |
| 8 | H (C) | GATOR complex protein NPRL3 | polymer | 569 | 63680.8 | 1 | UniProt (Q12980) Pfam (PF03666) | Homo sapiens (human) | -14 gene protein,Alpha-globin regulatory element-containing gene protein,Nitrogen permease regulator 3-like protein,Protein CGTHBA |
| 9 | I, P (D, K) | Ras-related GTP-binding protein A | polymer | 313 | 36615.2 | 2 | UniProt (Q7L523) Pfam (PF04670) | Homo sapiens (human) | RagA,Adenovirus E3 14.7 kDa-interacting protein 1,FIP-1 |
| 10 | J (E) | Ras-related GTP-binding protein C | polymer | 399 | 44195.7 | 1 | UniProt (Q9HB90) Pfam (PF04670) | Homo sapiens (human) | Rag C,RagC,GTPase-interacting protein 2,TIB929 |
| 11 | Q (L) | Ras-related GTP-binding protein C | polymer | 399 | 44298.9 | 1 | UniProt (Q9HB90) Pfam (PF04670) | Homo sapiens (human) | RagC,GTPase-interacting protein 2,TIB929 |
| 12 | R, T, V (D, E, K) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 3 | Chemie (GDP) | |||
| 13 | S, U, W (D, E, K) | ALUMINUM FLUORIDE | non-polymer | 84.0 | 3 | Chemie (AF3) |
Sequence modifications
E: 1 - 399 (UniProt: Q9HB90)
L: 1 - 399 (UniProt: Q9HB90)
| PDB | External Database | Details |
|---|---|---|
| Ala 92 | Phe 92 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 75 | Ser 75 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 17 |
| Total formula weight | 581183.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1581.5 | |
| All* | Total formula weight | 582764.8 |
