7T2D
Crystal structure of the B1 TCR in complex with HLA-DP4-Ply
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, K, P (A, F, K, P) | HLA class II histocompatibility antigen, DP alpha 1 chain | polymer | 181 | 20943.3 | 4 | UniProt (P20036) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | DP(W3),DP(W4),HLA-SB alpha chain,MHC class II DP3-alpha,MHC class II DPA1 |
| 2 | B, E, L, Q (B, G, L, Q) | HLA class II histocompatibility antigen, DP beta 1 chain | polymer | 188 | 21916.6 | 4 | UniProt (P04440) Pfam (PF00969) Pfam (PF07654) | Homo sapiens (human) | HLA class II histocompatibility antigen,DP(W4) beta chain,MHC class II antigen DPB1 |
| 3 | C, F, M, R (C, H, M, R) | Pneumolysin-derived peptide | polymer | 15 | 1826.0 | 4 | UniProt (Q04IN8) | Streptococcus pneumoniae | |
| 4 | G, I, N, S (D, I, N, S) | T cell receptor, B1, alpha chain | polymer | 207 | 23295.5 | 4 | UniProt (P01848) Pfam (PF09291) | Homo sapiens | |
| 5 | H, J, O, T (E, J, O, T) | T cell receptor, B1, beta chain | polymer | 243 | 27161.1 | 4 | UniProt (P01850) Pfam (PF07654) | Homo sapiens | |
| 6 | U (U) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 7 | V (V) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 8 | W, X (W, X) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 9 | AA, BA, CA, DA, EA... (F, G, K, L, P...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 10 | GA, HA, IA, JA, KA (A, C, F, E, I) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
C, H, M, R: -1 - 11 (UniProt: Q04IN8)
D, I, N, S: 1 - 129 (PDB: 7T2D)
D, I, N, S: 130 - 222 (UniProt: P01848)
E, J, O, T: 1 - 128 (PDB: 7T2D)
E, J, O, T: 129 - 257 (UniProt: P01850)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | cloning artifact |
| Ala -2 | - | cloning artifact |
D, I, N, S: 130 - 222 (UniProt: P01848)
| PDB | External Database | Details |
|---|---|---|
| Cys 176 | Thr 47 | engineered mutation |
E, J, O, T: 129 - 257 (UniProt: P01850)
| PDB | External Database | Details |
|---|---|---|
| Cys 184 | Ser 56 | engineered mutation |
| Ala 202 | Cys 74 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 20 |
| Total formula weight | 380570.3 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2670.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1769.7 | |
| All* | Total formula weight | 385010.4 |
