7T2C

Crystal structure of the B5 TCR in complex with HLA-DP4-Ply

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (D)	T cell receptor, B5, alpha chain	polymer	204	22664.1	1	UniProt (P01848) Pfam (PF09291)	Homo sapiens
2	B (E)	T cell receptor, B5, beta chain	polymer	249	27840.0	1	UniProt (P01850) Pfam (PF07654)	Homo sapiens
3	C (A)	HLA class II histocompatibility antigen, DP alpha 1 chain	polymer	181	20943.3	1	UniProt (P20036) Pfam (PF00993) Pfam (PF07654)	Homo sapiens (human)	T cell receptor alpha chain constant, DP(W3),DP(W4),HLA-SB alpha chain,MHC class II DP3-alpha,MHC class II DPA1
4	D (B)	HLA class II histocompatibility antigen, DP beta 1 chain	polymer	188	21916.6	1	UniProt (P04440) Pfam (PF00969) Pfam (PF07654)	Homo sapiens (human)	T cell receptor beta constant 1, HLA class II histocompatibility antigen,DP(W4) beta chain,MHC class II antigen DPB1
5	E (C)	Pneumolysin-derived peptide	polymer	15	1826.0	1	UniProt (Q04IN8)	Streptococcus pneumoniae
6	F (F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
7	G (E)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
8	H (B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
9	I, J, K (D, B, C)	water	water		18.0	3	Chemie (HOH)

Sequence modifications

D: 1 - 129 (PDB: 7T2C)
D: 130 - 222 (UniProt: P01848)

PDB	External Database	Details
Cys 176	Thr 47	engineered mutation

E: 1 - 128 (PDB: 7T2C)
E: 129 - 257 (UniProt: P01850)

PDB	External Database	Details
Cys 184	Ser 56	engineered mutation
Ala 202	Cys 74	engineered mutation

C: -1 - 11 (UniProt: Q04IN8)

PDB	External Database	Details
Gly -3	-	cloning artifact
Ala -2	-	cloning artifact

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.