7T1L
Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity phosphopeptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase Fes/Fps | polymer | 100 | 11201.9 | 2 | UniProt (P07332) Pfam (PF00017) | Homo sapiens (human) | Feline sarcoma/Fujinami avian sarcoma oncogene homolog,Proto-oncogene c-Fes,Proto-oncogene c-Fps,p93c-fes |
| 2 | C, D (C, D) | Synthetic phosphotyrosine-containing Ezrin-derived peptide | polymer | 7 | 879.9 | 2 | UniProt (P15311) | Homo sapiens | |
| 3 | E (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | F (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 181 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 100 (UniProt: P07332)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Glu 35 | Gln 486 | engineered mutation |
| Thr 36 | - | insertion |
| Val 37 | Gly 487 | engineered mutation |
| Gly 39 | Gln 489 | engineered mutation |
| Ala 40 | Glu 490 | engineered mutation |
| Ala 42 | Val 492 | engineered mutation |
| Leu 55 | Ile 505 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 24163.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 58.4 | |
| All* | Total formula weight | 24222.0 |
