7T1K
Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase Fes/Fps | polymer | 103 | 11613.3 | 1 | UniProt (P07332) Pfam (PF00017) | Homo sapiens (human) | Feline sarcoma/Fujinami avian sarcoma oncogene homolog,Proto-oncogene c-Fes,Proto-oncogene c-Fps,p93c-fes |
| 2 | B (B) | Synthetic phosphotyrosine-containing Ezrin-derived peptide | polymer | 7 | 879.9 | 1 | UniProt (P15311) | Homo sapiens | |
| 3 | C, D (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | E (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | F (A) | MALONATE ION | non-polymer | 102.0 | 1 | Chemie (MLI) | |||
| 6 | G, H (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 7 | I, J (A, B) | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
A: 2 - 100 (UniProt: P07332)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Gly 34 | Ser 485 | engineered mutation |
| Ser 36 | Gly 487 | engineered mutation |
| Gln 37 | Lys 488 | engineered mutation |
| Pro 38 | Gln 489 | engineered mutation |
| Asp 39 | Glu 490 | engineered mutation |
| Ser 101 | - | expression tag |
| Arg 102 | - | expression tag |
| Ala 103 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 12493.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 320.1 | |
| All* | Total formula weight | 12813.3 |
