7T0T
Crystal structure of the BCL6 BTB domain in complex with OICR-10562
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Isoform 2 of B-cell lymphoma 6 protein | polymer | 127 | 14559.8 | 6 | UniProt (P41182) Pfam (PF00651) | Homo sapiens (human) | BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51 |
| 2 | G, M (A, E) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 3 | H, I, J, K, L... (A, B, C, D, E...) | N-[5-chloro-2-(morpholin-4-yl)pyridin-4-yl]-2-[5-(3-cyano-4-hydroxy-5-methylphenyl)-3-methyl-2-(1-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]acetamide | non-polymer | 614.1 | 6 | Chemie (E1I) | |||
| 4 | O, P, Q, R, S... (A, B, C, D, E...) | water | water | 18.0 | 368 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 5 - 129 (UniProt: P41182)
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | expression tag |
| Ser 4 | - | expression tag |
| Gln 8 | Cys 8 | engineered mutation |
| Arg 67 | Cys 67 | engineered mutation |
| Asn 84 | Cys 84 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 87358.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3840.6 | |
| All* | Total formula weight | 91199.5 |
