7SZ0
Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. "tips-juxtaposed" conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Epidermal growth factor receptor | polymer | 1210 | 134477.4 | 2 | UniProt (P00533) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) Pfam (PF21314) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | C, D | Epidermal growth factor | polymer | 53 | 6229.0 | 2 | UniProt (P01133) Pfam (PF00008) In PDB | Homo sapiens (human) | Urogastrone |
Sequence modifications
A, B: -23 - 1186 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Asn 232 | Asp 256 | conflict |
| Arg 834 | Leu 858 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 281412.8 | |
| All* | Total formula weight | 281412.8 |
