7SYX

Structure of the delta dII IRES eIF5B-containing 48S initiation complex, closed conformation. Structure 15(delta dII)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	2	18S rRNA	polymer	1870	603100.9	1		Oryctolagus cuniculus (Rabbit)
2	A	Eukaryotic translation initiation factor 1A, X-chromosomal	polymer	144	16488.4	1	UniProt (P47813) Pfam (PF01176) In PDB	Homo sapiens (human)	eIF-1A X isoform,Eukaryotic translation initiation factor 4C,eIF-4C
3	B	uS2	polymer	295	32928.0	1	UniProt (G1TLT8) Pfam (PF00318) Pfam (PF16122) In PDB	Oryctolagus cuniculus (rabbit)	40S ribosomal protein SA, 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40
4	C	eS1	polymer	264	30002.1	1	UniProt (G1SS70) Pfam (PF01015) In PDB	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S3a
5	D	uS5	polymer	221	24441.8	1	UniProt (by SIFTS) (G1SV32) In PDB	Oryctolagus cuniculus (Rabbit)
6	E	uS3	polymer	281	31146.6	1	UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189) In PDB	Oryctolagus cuniculus (rabbit)	Ribosomal protein S3
7	F	eS4	polymer	262	29497.7	1	UniProt (G1TK17) Pfam (PF00467) Pfam (PF16121) Pfam (PF08071) Pfam (PF00900) In PDB	Oryctolagus cuniculus (rabbit)
8	G	uS7	polymer	204	22913.5	1	UniProt (G1TFM5) Pfam (PF00177) In PDB	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S5
9	H	eS6	polymer	249	28751.9	1	UniProt (G1TM55) Pfam (PF01092) UniProt (by SIFTS) (A0A5K1UJS7) In PDB	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S6
10	I	40S ribosomal protein S7	polymer	432	47356.2	1	UniProt (G1SVB0) In PDB	Oryctolagus cuniculus (rabbit)
11	J	eS8	polymer	208	24263.4	1	UniProt (G1TJW1) Pfam (PF01201) In PDB	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S8
12	K	uS4	polymer	194	22641.6	1	UniProt (B7NZS8) Pfam (PF00163) Pfam (PF01479) In PDB	Oryctolagus cuniculus (rabbit)	Ribosomal protein S9
13	L	eS10	polymer	149	17156.9	1	UniProt (G1TPV3) Pfam (PF03501) In PDB	Oryctolagus cuniculus (rabbit)
14	M	uS17	polymer	158	18468.8	1	UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366) In PDB	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S11
15	N	eS12	polymer	132	14539.0	1	UniProt (G1SFR8) Pfam (PF01248) In PDB	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S12
16	O	uS15	polymer	151	17259.4	1	UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312) In PDB	Oryctolagus cuniculus (rabbit)	Ribosomal protein S13
17	P	uS11	polymer	168	18134.0	1	UniProt (G1U472) Pfam (PF00411) UniProt (by SIFTS) (G1T1F0) In PDB	Oryctolagus cuniculus (rabbit)
18	Q	uS19	polymer	145	17049.2	1	UniProt (G1U0Q2) Pfam (PF00203) In PDB	Oryctolagus cuniculus (rabbit)
19	R	uS9	polymer	172	19213.5	1	UniProt (G1SGX4) Pfam (PF00380) In PDB	Oryctolagus cuniculus (rabbit)	Ribosomal protein S16
20	S	eS17	polymer	135	15552.1	1	UniProt (G1TU13) Pfam (PF00833) In PDB	Oryctolagus cuniculus (rabbit)
21	T	uS13	polymer	152	17759.8	1	UniProt (G1TPG3) Pfam (PF00416) In PDB	Oryctolagus cuniculus (rabbit)
22	U	eS19	polymer	145	16235.8	1	UniProt (G1TN62) Pfam (PF01090) In PDB	Oryctolagus cuniculus (rabbit)
23	V	uS10	polymer	119	13398.8	1	UniProt (G1SIZ2) Pfam (PF00338) In PDB	Oryctolagus cuniculus (rabbit)
24	W	eS21	polymer	83	9023.2	1		Oryctolagus cuniculus (Rabbit)
25	X	uS8	polymer	130	14865.6	1	UniProt (G1TG89) Pfam (PF00410) In PDB	Oryctolagus cuniculus (rabbit)	Ribosomal protein S15a
26	Y	uS12	polymer	143	15844.7	1	UniProt (G1SZ47) Pfam (PF00164) In PDB	Oryctolagus cuniculus (rabbit)
27	Z	40S ribosomal protein S24	polymer	131	15237.1	1	UniProt (G1T3D8) Pfam (PF01282) In PDB	Oryctolagus cuniculus (rabbit)
28	a	40S ribosomal protein S25	polymer	124	13645.0	1	UniProt (G1TDB3) Pfam (PF03297) In PDB	Oryctolagus cuniculus (rabbit)
29	b	eS26	polymer	101	11619.8	1	UniProt (G1TFE8) Pfam (PF01283) In PDB	Oryctolagus cuniculus (rabbit)
30	c	eS27	polymer	84	9480.2	1	UniProt (G1TZ76) Pfam (PF01667) In PDB	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S27
31	d	eS28	polymer	69	7855.1	1	UniProt (G1TIB4) Pfam (PF01200) In PDB	Oryctolagus cuniculus (rabbit)	Ribosomal protein S28
32	e	eS29	polymer	56	6690.8	1	UniProt (G1U7M4) Pfam (PF00253) In PDB	Oryctolagus cuniculus (rabbit)
33	f	eS30	polymer	133	14498.9	1	UniProt (G1T8A2) Pfam (PF00240) Pfam (PF04758) In PDB	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S30
34	g	40S ribosomal protein S27a	polymer	188	21431.7	1	UniProt (G1SK22) Pfam (PF00240) Pfam (PF01599) In PDB	Oryctolagus cuniculus (rabbit)	Ubiquitin carboxyl extension protein 80,Ubiquitin-40S ribosomal protein S27a
35	h	RACK1	polymer	317	35115.7	1	UniProt (G1SJB4) Pfam (PF00400) In PDB	Oryctolagus cuniculus (rabbit)
36	i	Met-tRNA-i-Met	polymer	75	24231.5	1		Oryctolagus cuniculus (Rabbit)
37	n	60s ribosomal protein l41	polymer	25	3473.5	1	UniProt (A0A087WNH4) Pfam (PF05162) In PDB	Oryctolagus cuniculus (rabbit)
38	x	Eukaryotic translation initiation factor 5B	polymer	627	70788.0	1	UniProt (G1TRL5) Pfam (PF00009) Pfam (PF11987) Pfam (PF14578) In PDB	Oryctolagus cuniculus (rabbit)	Translation initiation factor IF-2
39	z	HCV IRES	polymer	400	128746.1	1	GenBank (149384897)	Hepatitis C virus (isolate 1)
40	b	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
41	x	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
42	x	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	1	Chemie (GTP)

Sequence modifications

F: 2 - 263 (UniProt: G1TK17)

PDB	External Database	Details
Gly 25	Ser 25	conflict

J: 1 - 208 (UniProt: G1TJW1)

PDB	External Database	Details
Arg 47	Gly 47	conflict

Contents of the asymmetric unit

Polymers	Number of chains	39
	Total formula weight	1500846.0
Non-Polymers*	Number of molecules	3
	Total formula weight	612.9
All*	Total formula weight	1501458.9

*Water molecules are not included.