7SYX
Structure of the delta dII IRES eIF5B-containing 48S initiation complex, closed conformation. Structure 15(delta dII)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (2) | 18S rRNA | polymer | 1870 | 603100.9 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 2 | B (A) | Eukaryotic translation initiation factor 1A, X-chromosomal | polymer | 144 | 16488.4 | 1 | UniProt (P47813) Pfam (PF01176) | Homo sapiens (human) | eIF-1A X isoform,Eukaryotic translation initiation factor 4C,eIF-4C |
| 3 | C (B) | uS2 | polymer | 295 | 32928.0 | 1 | UniProt (G1TLT8) Pfam (PF00318) Pfam (PF16122) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein SA, 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40 |
| 4 | D (C) | eS1 | polymer | 264 | 30002.1 | 1 | UniProt (G1SS70) Pfam (PF01015) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S3a |
| 5 | E (D) | uS5 | polymer | 221 | 24441.8 | 1 | UniProt (by SIFTS) (G1SV32) | Oryctolagus cuniculus (Rabbit) | |
| 6 | F (E) | uS3 | polymer | 281 | 31146.6 | 1 | UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189) | Oryctolagus cuniculus (rabbit) | Ribosomal protein S3 |
| 7 | G (F) | eS4 | polymer | 262 | 29497.7 | 1 | UniProt (G1TK17) Pfam (PF00467) Pfam (PF16121) Pfam (PF08071) Pfam (PF00900) | Oryctolagus cuniculus (rabbit) | |
| 8 | H (G) | uS7 | polymer | 204 | 22913.5 | 1 | UniProt (G1TFM5) Pfam (PF00177) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S5 |
| 9 | I (H) | eS6 | polymer | 249 | 28751.9 | 1 | UniProt (G1TM55) Pfam (PF01092) UniProt (by SIFTS) (A0A5K1UJS7) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S6 |
| 10 | J (I) | 40S ribosomal protein S7 | polymer | 432 | 47356.2 | 1 | UniProt (G1SVB0) Pfam (PF01251) | Oryctolagus cuniculus (rabbit) | |
| 11 | K (J) | eS8 | polymer | 208 | 24263.4 | 1 | UniProt (G1TJW1) Pfam (PF01201) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S8 |
| 12 | L (K) | uS4 | polymer | 194 | 22641.6 | 1 | UniProt (B7NZS8) Pfam (PF00163) Pfam (PF01479) | Oryctolagus cuniculus (rabbit) | Ribosomal protein S9 |
| 13 | M (L) | eS10 | polymer | 149 | 17156.9 | 1 | UniProt (G1TPV3) Pfam (PF03501) | Oryctolagus cuniculus (rabbit) | |
| 14 | N (M) | uS17 | polymer | 158 | 18468.8 | 1 | UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S11 |
| 15 | O (N) | eS12 | polymer | 132 | 14539.0 | 1 | UniProt (G1SFR8) Pfam (PF01248) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S12 |
| 16 | P (O) | uS15 | polymer | 151 | 17259.4 | 1 | UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312) | Oryctolagus cuniculus (rabbit) | Ribosomal protein S13 |
| 17 | Q (P) | uS11 | polymer | 168 | 18134.0 | 1 | UniProt (G1U472) Pfam (PF00411) UniProt (by SIFTS) (G1T1F0) | Oryctolagus cuniculus (rabbit) | |
| 18 | R (Q) | uS19 | polymer | 145 | 17049.2 | 1 | UniProt (G1U0Q2) Pfam (PF00203) | Oryctolagus cuniculus (rabbit) | |
| 19 | S (R) | uS9 | polymer | 172 | 19213.5 | 1 | UniProt (G1SGX4) Pfam (PF00380) | Oryctolagus cuniculus (rabbit) | Ribosomal protein S16 |
| 20 | T (S) | eS17 | polymer | 135 | 15552.1 | 1 | UniProt (G1TU13) Pfam (PF00833) | Oryctolagus cuniculus (rabbit) | |
| 21 | U (T) | uS13 | polymer | 152 | 17759.8 | 1 | UniProt (G1TPG3) Pfam (PF00416) | Oryctolagus cuniculus (rabbit) | |
| 22 | V (U) | eS19 | polymer | 145 | 16235.8 | 1 | UniProt (G1TN62) Pfam (PF01090) | Oryctolagus cuniculus (rabbit) | |
| 23 | W (V) | uS10 | polymer | 119 | 13398.8 | 1 | UniProt (G1SIZ2) Pfam (PF00338) | Oryctolagus cuniculus (rabbit) | |
| 24 | X (W) | eS21 | polymer | 83 | 9023.2 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 25 | Y (X) | uS8 | polymer | 130 | 14865.6 | 1 | UniProt (G1TG89) Pfam (PF00410) | Oryctolagus cuniculus (rabbit) | Ribosomal protein S15a |
| 26 | Z (Y) | uS12 | polymer | 143 | 15844.7 | 1 | UniProt (G1SZ47) Pfam (PF00164) | Oryctolagus cuniculus (rabbit) | |
| 27 | AA (Z) | 40S ribosomal protein S24 | polymer | 131 | 15237.1 | 1 | UniProt (G1T3D8) Pfam (PF01282) | Oryctolagus cuniculus (rabbit) | |
| 28 | BA (a) | 40S ribosomal protein S25 | polymer | 124 | 13645.0 | 1 | UniProt (G1TDB3) Pfam (PF03297) | Oryctolagus cuniculus (rabbit) | |
| 29 | CA (b) | eS26 | polymer | 101 | 11619.8 | 1 | UniProt (G1TFE8) Pfam (PF01283) | Oryctolagus cuniculus (rabbit) | |
| 30 | DA (c) | eS27 | polymer | 84 | 9480.2 | 1 | UniProt (G1TZ76) Pfam (PF01667) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S27 |
| 31 | EA (d) | eS28 | polymer | 69 | 7855.1 | 1 | UniProt (G1TIB4) Pfam (PF01200) | Oryctolagus cuniculus (rabbit) | Ribosomal protein S28 |
| 32 | FA (e) | eS29 | polymer | 56 | 6690.8 | 1 | UniProt (G1U7M4) Pfam (PF00253) | Oryctolagus cuniculus (rabbit) | |
| 33 | GA (f) | eS30 | polymer | 133 | 14498.9 | 1 | UniProt (G1T8A2) Pfam (PF00240) Pfam (PF04758) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S30 |
| 34 | HA (g) | 40S ribosomal protein S27a | polymer | 188 | 21431.7 | 1 | UniProt (G1SK22) Pfam (PF00240) Pfam (PF01599) | Oryctolagus cuniculus (rabbit) | Ubiquitin carboxyl extension protein 80,Ubiquitin-40S ribosomal protein S27a |
| 35 | IA (h) | RACK1 | polymer | 317 | 35115.7 | 1 | UniProt (G1SJB4) Pfam (PF00400) | Oryctolagus cuniculus (rabbit) | |
| 36 | JA (i) | Met-tRNA-i-Met | polymer | 75 | 24231.5 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 37 | KA (n) | 60s ribosomal protein l41 | polymer | 25 | 3473.5 | 1 | UniProt (A0A087WNH4) Pfam (PF05162) | Oryctolagus cuniculus (rabbit) | |
| 38 | LA (x) | Eukaryotic translation initiation factor 5B | polymer | 627 | 70788.0 | 1 | UniProt (G1TRL5) Pfam (PF00009) Pfam (PF11987) Pfam (PF14578) | Oryctolagus cuniculus (rabbit) | Translation initiation factor IF-2 |
| 39 | MA (z) | HCV IRES | polymer | 400 | 128746.1 | 1 | GenBank (149384897) | Hepatitis C virus (isolate 1) | |
| 40 | NA (b) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 41 | OA (x) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 42 | PA (x) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) |
Sequence modifications
F: 2 - 263 (UniProt: G1TK17)
J: 1 - 208 (UniProt: G1TJW1)
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | Ser 25 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 47 | Gly 47 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 39 |
| Total formula weight | 1500846.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 612.9 | |
| All* | Total formula weight | 1501458.9 |
