7SYR
Structure of the wt IRES eIF2-containing 48S initiation complex, closed conformation. Structure 12(wt).
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | 2 | 18S rRNA | polymer | 1870 | 603100.9 | 1 | Oryctolagus cuniculus (rabbit) | ||
2 | A | Eukaryotic translation initiation factor 1A, X-chromosomal | polymer | 144 | 16488.4 | 1 | UniProt (P47813) Pfam (PF01176) In PDB | Homo sapiens (human) | eIF-1A X isoform,Eukaryotic translation initiation factor 4C,eIF-4C |
3 | B | uS2 (SA) | polymer | 295 | 32958.0 | 1 | UniProt (G1TLT8) Pfam (PF00318) Pfam (PF16122) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein SA, 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40 |
4 | C | eS1 | polymer | 264 | 30002.1 | 1 | UniProt (G1SS70) Pfam (PF01015) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S3a |
5 | D | uS5 | polymer | 221 | 24441.8 | 1 | UniProt (by SIFTS) (G1SV32) In PDB | Oryctolagus cuniculus (rabbit) | |
6 | E | uS3 | polymer | 281 | 31146.6 | 1 | UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189) In PDB | Oryctolagus cuniculus (rabbit) | Ribosomal protein S3 |
7 | F | eS4 (S4 X isoform) | polymer | 263 | 29654.9 | 1 | UniProt (G1TK17) Pfam (PF00467) Pfam (PF16121) Pfam (PF08071) Pfam (PF00900) UniProt (by SIFTS) (G1TA47) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S4 |
8 | G | uS7 | polymer | 204 | 22913.5 | 1 | UniProt (G1TFM5) Pfam (PF00177) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S5 |
9 | H | eS6 | polymer | 249 | 28751.9 | 1 | UniProt (G1TM55) Pfam (PF01092) UniProt (by SIFTS) (A0A5K1UJS7) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S6 |
10 | I | eS7 | polymer | 432 | 47356.2 | 1 | UniProt (G1SVB0) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S7 |
11 | J | eS8 | polymer | 208 | 24263.4 | 1 | UniProt (G1TJW1) Pfam (PF01201) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S8 |
12 | K | uS4 | polymer | 194 | 22641.6 | 1 | UniProt (B7NZS8) Pfam (PF00163) Pfam (PF01479) In PDB | Oryctolagus cuniculus (rabbit) | Ribosomal protein S9 |
13 | L | eS10 | polymer | 149 | 17156.9 | 1 | UniProt (G1TPV3) Pfam (PF03501) In PDB | Oryctolagus cuniculus (rabbit) | |
14 | M | uS17 | polymer | 158 | 18468.8 | 1 | UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S11 |
15 | N | eS12 | polymer | 132 | 14539.0 | 1 | UniProt (G1SFR8) Pfam (PF01248) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S12 |
16 | O | uS15 | polymer | 151 | 17259.4 | 1 | UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312) In PDB | Oryctolagus cuniculus (rabbit) | Ribosomal protein S13 |
17 | P | uS11 | polymer | 168 | 18134.0 | 1 | UniProt (G1U472) Pfam (PF00411) UniProt (by SIFTS) (G1T1F0) In PDB | Oryctolagus cuniculus (rabbit) | |
18 | Q | uS19 | polymer | 145 | 17049.2 | 1 | UniProt (G1U0Q2) Pfam (PF00203) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S15 |
19 | R | uS9 | polymer | 172 | 19213.5 | 1 | UniProt (G1SGX4) Pfam (PF00380) In PDB | Oryctolagus cuniculus (rabbit) | Ribosomal protein S16 |
20 | S | eS17 | polymer | 135 | 15552.1 | 1 | UniProt (G1TU13) Pfam (PF00833) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S17 |
21 | T | uS13 | polymer | 152 | 17759.8 | 1 | UniProt (G1TPG3) Pfam (PF00416) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S18 |
22 | U | eS19 | polymer | 145 | 16235.8 | 1 | UniProt (G1TN62) Pfam (PF01090) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S19 |
23 | V | uS10 | polymer | 119 | 13398.8 | 1 | UniProt (G1SIZ2) Pfam (PF00338) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S20 |
24 | W | eS21 | polymer | 83 | 9124.4 | 1 | UniProt (G1TM82) Pfam (PF01249) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S21 |
25 | X | uS8 | polymer | 130 | 14865.6 | 1 | UniProt (G1TG89) Pfam (PF00410) In PDB | Oryctolagus cuniculus (rabbit) | 40S Ribosomal protein S15a |
26 | Y | uS12 | polymer | 143 | 15844.7 | 1 | UniProt (G1SZ47) Pfam (PF00164) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S23 |
27 | Z | eS24 | polymer | 131 | 15237.1 | 1 | UniProt (G1T3D8) Pfam (PF01282) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S24 |
28 | a | eS25 | polymer | 124 | 13645.0 | 1 | UniProt (G1TDB3) Pfam (PF03297) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S25 |
29 | b | eS26 | polymer | 101 | 11645.8 | 1 | UniProt (G1TFE8) Pfam (PF01283) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S26 |
30 | c | eS27 | polymer | 84 | 9480.2 | 1 | UniProt (G1TZ76) Pfam (PF01667) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S27 |
31 | d | eS28 | polymer | 69 | 7855.1 | 1 | UniProt (G1TIB4) Pfam (PF01200) In PDB | Oryctolagus cuniculus (rabbit) | 40S Ribosomal protein S28 |
32 | e | uS14 | polymer | 56 | 6690.8 | 1 | UniProt (G1U7M4) Pfam (PF00253) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S29 |
33 | f | eS30 | polymer | 133 | 14498.9 | 1 | UniProt (G1T8A2) Pfam (PF00240) Pfam (PF04758) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S30 |
34 | g | eS31 | polymer | 188 | 21431.7 | 1 | UniProt (G1SK22) Pfam (PF00240) Pfam (PF01599) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S27a, Ubiquitin carboxyl extension protein 80,Ubiquitin-40S ribosomal protein S27a |
35 | h | Receptor for Activated C Kinase 1 (RACK1) | polymer | 317 | 35115.7 | 1 | UniProt (G1SJB4) Pfam (PF00400) In PDB | Oryctolagus cuniculus (rabbit) | |
36 | i | Met-tRNA-i-Met | polymer | 75 | 24231.5 | 1 | GenBank (174924) | Oryctolagus cuniculus (rabbit) | |
37 | j | Eukaryotic translation initiation factor 2 subunit 1 | polymer | 315 | 36161.2 | 1 | UniProt (P05198) Pfam (PF00575) Pfam (PF07541) In PDB | Homo sapiens (human) | Eukaryotic translation initiation factor 2 subunit alpha,eIF-2alpha |
38 | n | eL41 | polymer | 25 | 3473.5 | 1 | UniProt (A0A087WNH4) Pfam (PF05162) In PDB | Oryctolagus cuniculus (rabbit) | 60s ribosomal protein l41 |
39 | z | HCV IRES | polymer | 400 | 128746.1 | 1 | GenBank (149384897) | Hepatitis C virus (isolate 1) | |
40 | b | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
B: 1 - 295 (UniProt: G1TLT8)
F: 1 - 263 (UniProt: G1TK17)
J: 1 - 208 (UniProt: G1TJW1)
W: 1 - 83 (UniProt: G1TM82)
b: 2 - 102 (UniProt: G1TFE8)
PDB | External Database | Details |
---|---|---|
Thr 114 | Ala 114 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 25 | Ser 25 | conflict |
Arg 51 | Lys 51 | conflict |
Thr 78 | Ala 78 | conflict |
Val 156 | Met 156 | conflict |
PDB | External Database | Details |
---|---|---|
Arg 47 | Gly 47 | conflict |
PDB | External Database | Details |
---|---|---|
Asn 3 | Ser 3 | conflict |
Asp 4 | Asn 4 | conflict |
Gln 33 | Pro 33 | conflict |
Phe 50 | Ser 50 | conflict |
Ala 75 | Ser 75 | conflict |
Asp 76 | His 76 | conflict |
Lys 81 | Gln 81 | conflict |
PDB | External Database | Details |
---|---|---|
Arg 28 | Cys 28 | conflict |
Ala 56 | Val 56 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 39 |
Total formula weight | 1466533.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 65.4 | |
All* | Total formula weight | 1466599.0 |