7SXE
Crystal structure of ligase I with nick duplexes containing cognate G:T
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA ligase 1 | polymer | 669 | 74326.7 | 1 | UniProt (P18858) Pfam (PF04675) Pfam (PF01068) Pfam (PF04679) | Homo sapiens (Human) | DNA ligase I,Polydeoxyribonucleotide synthase [ATP] 1 |
| 2 | B (B) | DNA chain 1 | polymer | 11 | 3405.2 | 1 | synthetic construct | ||
| 3 | C (C) | DNA chain 2 | polymer | 7 | 2138.4 | 1 | synthetic construct | ||
| 4 | D (D) | DNA chain 3 | polymer | 18 | 5461.5 | 1 | synthetic construct | ||
| 5 | E (A) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 1 | Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (34768) PubChem (83862) PubChem (40467049) PubChem (40469468) PubChem (446048) PubChem (44348067) PubChem (45358029) PubChem (40459109) PubChem (515384) PubChem (46874558) PubChem (638042) PubChem (46875232) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (5316444) PubChem (5742864) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (12163610) PubChem (12358355) PubChem (92144436) PubChem (122197642) PubChem (12358354) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 6 | F, G, H, I (A, B, C, D) | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A: 261 - 918 (UniProt: P18858)
| PDB | External Database | Details |
|---|---|---|
| Ala 346 | Glu 346 | conflict |
| Ala 592 | Glu 592 | conflict |
| Ala 919 | - | expression tag |
| Ala 920 | - | expression tag |
| Ala 921 | - | expression tag |
| Leu 922 | - | expression tag |
| Glu 923 | - | expression tag |
| His 924 | - | expression tag |
| His 925 | - | expression tag |
| His 926 | - | expression tag |
| His 927 | - | expression tag |
| His 928 | - | expression tag |
| His 929 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 85331.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 347.2 | |
| All* | Total formula weight | 85679.1 |
