7SU1
Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.106 in complex with CTLA-4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | Fab heavy chain | polymer | 229 | 24786.7 | 1 | Homo sapiens (human) | ||
| 2 | B (L) | Fab light chain | polymer | 215 | 23527.0 | 1 | Homo sapiens (human) | ||
| 3 | C (C) | Cytotoxic T-lymphocyte protein 4 | polymer | 125 | 13555.4 | 1 | UniProt (P16410) Pfam (PF07686) | Homo sapiens (Human) | Cytotoxic T-lymphocyte-associated antigen 4,CTLA-4 |
| 4 | D (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E, F, G (H, L, C) | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence modifications
C: 1 - 118 (UniProt: P16410)
| PDB | External Database | Details |
|---|---|---|
| Gly 119 | - | expression tag |
| His 120 | - | expression tag |
| His 121 | - | expression tag |
| His 122 | - | expression tag |
| His 123 | - | expression tag |
| His 124 | - | expression tag |
| His 125 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 61869.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 62090.4 |
