7SSK

Human P300 complexed with a glycine-based inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Histone acetyltransferase p300	polymer	569	66193.4	1	UniProt (Q09472) Pfam (PF00439) Pfam (PF06001) Pfam (PF23570) Pfam (PF08214)	Homo sapiens (Human)	p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein 2-hydroxyisobutyryltransferase p300,Protein lactyltransferas p300,Protein propionyltransferase p300
2	B, C (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D (A)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
4	E (A)	N-[2-(4-methoxyanilino)-2-oxoethyl]-N-methyl-1-phenylcyclopentane-1-carboxamide	non-polymer		366.5	1	Chemie (C3I)
5	F (A)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
6	G (A)	water	water		18.0	222	Chemie (HOH)

Sequence modifications

A: 1048 - 1576 (UniProt: Q09472)

PDB	External Database	Details
Gly 1039	-	expression tag
Gly 1040	-	expression tag
His 1041	-	expression tag
His 1042	-	expression tag
His 1043	-	expression tag
His 1044	-	expression tag
His 1045	-	expression tag
His 1046	-	expression tag
Gly 1047	-	expression tag
Phe 1467	Tyr 1467	engineered mutation

A: 1582 - 1664 (UniProt: Q09472)

PDB	External Database	Details
Ser 1577	-	linker
Gly 1578	-	linker
Gly 1579	-	linker
Ser 1580	-	linker
Gly 1581	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	66193.4
Non-Polymers*	Number of molecules	5
	Total formula weight	618.4
All*	Total formula weight	66811.8

*Water molecules are not included.