7SQM
Discovery and Preclinical Pharmacology of INE963, A Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cure in Uncomplicated Malaria
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase haspin | polymer | 357 | 40383.2 | 1 | UniProt (Q8TF76) Pfam (PF12330) | Homo sapiens (Human) | Germ cell-specific gene 2 protein,H-haspin,Haploid germ cell-specific nuclear protein kinase |
| 2 | B (A) | 1-[(4S)-5-(2,4-difluorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-4-methylpiperidin-4-amine | non-polymer | 349.4 | 1 | Chemie (A5G) | |||
| 3 | C, D (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | E (A) | water | water | 18.0 | 423 | Chemie (HOH) |
Sequence modifications
A: 445 - 798 (UniProt: Q8TF76)
| PDB | External Database | Details |
|---|---|---|
| Gly 442 | - | expression tag |
| Pro 443 | - | expression tag |
| Gly 444 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40383.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 533.6 | |
| All* | Total formula weight | 40916.8 |
