7SPO

Crystal structure of the SARS-CoV-2 receptor binding domain in complex with VNAR 3B4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Spike protein S1	polymer	213	24003.8	2	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2
2	C, D (C, D)	VNAR 3B4	polymer	141	15607.3	2		Squalus acanthias (Arabian camel)
3	E, F (L, M)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	2	In PDB GlyTouCan (G21290RB)
4	G, H, I, J, K... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	7	Chemie (EDO)
5	N, O, P, Q (A, B, C, D)	water	water		18.0	247	Chemie (HOH)

Sequence modifications

A, B: 330 - 532 (UniProt: P0DTC2)

PDB	External Database	Details
Glu 327	-	expression tag
Thr 328	-	expression tag
Gly 329	-	expression tag
Lys 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag
His 537	-	expression tag
His 538	-	expression tag
His 539	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	79222.3
Branched	Number of molecules	2
	Total formula weight	1141.1
Non-Polymers*	Number of molecules	7
	Total formula weight	434.5
All*	Total formula weight	80797.9

*Water molecules are not included.