7SKA
Sub-tomogram averaged structure of HIV-1 Envelope protein in native membrane
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, N, Y) | Envelope glycoprotein gp120 | polymer | 465 | 52171.0 | 3 | UniProt (Q6TAN8) Pfam (PF00516) | Human immunodeficiency virus 1 | Env polyprotein |
| 2 | B, D, F (B, O, Z) | Envelope glycoprotein gp41 | polymer | 144 | 16420.6 | 3 | UniProt (Q6TAN8) Pfam (PF00517) | Human immunodeficiency virus 1 | Env polyprotein |
| 3 | CA, G, KA, N, SA... (b, F, j, J, s...) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 6 | ||||
| 4 | H, LA, W (H, k, d) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 3 | ||||
| 5 | AA, I, J, K, L... (X, C, D, E, G...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 12 | ||||
| 6 | BA, EA, M, P, RA... (a, e, I, L, r...) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 6 | ||||
| 7 | DA, FA, O, Q, TA... (c, f, K, M, t...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 6 | ||||
| 8 | GA, R, WA (n, P, w) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(2-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1098.0 | 3 | ||||
| 9 | HA, S, XA (g, Q, x) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1479.3 | 3 | ||||
| 10 | IA, T, YA (h, R, y) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose | branched | 383.3 | 3 | ||||
| 11 | JA, NA, U (i, m, S) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 3 | ||||
| 12 | AB, BB, CB, DB, EB... (A, B, N, O, Y...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 21 | Chemie (NAG) | |||
| 13 | GB, OB, WB (B, O, Z) | alpha-L-fucopyranose | non-polymer | 164.2 | 3 | Chemie (FUC) |
Sequence modifications
B, O, Z: 521 - 664 (UniProt: Q6TAN8)
| PDB | External Database | Details |
|---|---|---|
| Met 535 | Ile 533 | conflict |
| Gln 543 | Leu 541 | conflict |
| Arg 574 | Lys 572 | conflict |
| Asn 625 | His 623 | conflict |
| Met 626 | Thr 624 | conflict |
| Ala 649 | Ser 647 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 205774.7 | |
| Branched | Number of molecules | 45 |
| Total formula weight | 33889.0 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 5137.8 | |
| All* | Total formula weight | 244801.5 |
