7SK3
Cryo-EM structure of ACKR3 in complex with CXCL12, an intracellular Fab, and an extracellular Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Atypical chemokine receptor 3 | polymer | 393 | 45196.4 | 1 | UniProt (P25106) Pfam (PF00001) In PDB | Homo sapiens (human) | C-X-C chemokine receptor type 7,CXC-R7,CXCR-7,Chemokine orphan receptor 1,G-protein coupled receptor 159,G-protein coupled receptor RDC1 homolog,RDC-1 |
| 2 | B | Stromal cell-derived factor 1 | polymer | 68 | 7978.5 | 1 | UniProt (P48061) Pfam (PF00048) In PDB | Homo sapiens (human) | hSDF-1,C-X-C motif chemokine 12,Intercrine reduced in hepatomas,hIRH,Pre-B cell growth-stimulating factor,PBSF |
| 3 | C | CID25 Fab light chain | polymer | 215 | 23531.1 | 1 | Homo sapiens | ||
| 4 | D | CID25 Fab heavy chain | polymer | 236 | 25461.4 | 1 | Homo sapiens | ||
| 5 | E | CID24 Fab light chain | polymer | 215 | 23471.0 | 1 | Homo sapiens | ||
| 6 | F | CID24 Fab heavy chain | polymer | 238 | 25380.2 | 1 | Homo sapiens | ||
| 7 | A | CHOLESTEROL | non-polymer | 386.7 | 8 | Chemie (CLR) |
Sequence modifications
A: 2 - 362 (UniProt: P25106)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | cloning artifact |
| Ala 0 | - | cloning artifact |
| Pro 1 | - | cloning artifact |
| Gly 363 | - | expression tag |
| Arg 364 | - | expression tag |
| Pro 365 | - | expression tag |
| Leu 366 | - | expression tag |
| Glu 367 | - | expression tag |
| Val 368 | - | expression tag |
| Leu 369 | - | expression tag |
| Phe 370 | - | expression tag |
| Gln 371 | - | expression tag |
| Gly 372 | - | expression tag |
| Pro 373 | - | expression tag |
| His 374 | - | expression tag |
| His 375 | - | expression tag |
| His 376 | - | expression tag |
| His 377 | - | expression tag |
| His 378 | - | expression tag |
| His 379 | - | expression tag |
| His 380 | - | expression tag |
| His 381 | - | expression tag |
| His 382 | - | expression tag |
| His 383 | - | expression tag |
| Asp 384 | - | expression tag |
| Tyr 385 | - | expression tag |
| Lys 386 | - | expression tag |
| Asp 387 | - | expression tag |
| Asp 388 | - | expression tag |
| Asp 389 | - | expression tag |
| Asp 390 | - | expression tag |
| Lys 391 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 151018.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3093.2 | |
| All* | Total formula weight | 154111.9 |
