7SHY
IgE-Fc in complex with omalizumab scFv
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, J (I, K, C, E) | Omalizumab VH | polymer | 122 | 13362.7 | 4 | Homo sapiens | ||
| 2 | D, E, F, K (J, L, D, F) | Omalizumab VL | polymer | 134 | 14665.8 | 4 | Homo sapiens | ||
| 3 | G, H, I, L (A, G, H, B) | IgE Fc | polymer | 247 | 27550.9 | 4 | UniProt (P01854) Pfam (PF07654) | Homo sapiens (Human) | Immunoglobulin heavy constant epsilon, Ig epsilon chain C region,Ig epsilon chain C region ND |
| 4 | M (M) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(2-3)-[alpha-L-fucopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1057.0 | 1 | ||||
| 5 | N (N) | beta-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | ||||
| 6 | O (O) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | ||||
| 7 | P (P) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | ||||
| 8 | Q (D) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 9 | R, T, U (A, H, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 10 | S (H) | alpha-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (MAN) | |||
| 11 | V, W, X, Y, Z (K, L, D, G, B) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, G, H, B: 328 - 545 (UniProt: P01854)
| PDB | External Database | Details |
|---|---|---|
| Ala 299 | - | expression tag |
| Pro 300 | - | expression tag |
| Met 301 | - | expression tag |
| Ala 302 | - | expression tag |
| Glu 303 | - | expression tag |
| Gly 304 | - | expression tag |
| Gly 305 | - | expression tag |
| Gly 306 | - | expression tag |
| Gln 307 | - | expression tag |
| Asn 308 | - | expression tag |
| His 309 | - | expression tag |
| His 310 | - | expression tag |
| His 311 | - | expression tag |
| His 312 | - | expression tag |
| His 313 | - | expression tag |
| His 314 | - | expression tag |
| His 315 | - | expression tag |
| His 316 | - | expression tag |
| Gly 317 | - | expression tag |
| Gly 318 | - | expression tag |
| Glu 319 | - | expression tag |
| Asn 320 | - | expression tag |
| Leu 321 | - | expression tag |
| Tyr 322 | - | expression tag |
| Phe 323 | - | expression tag |
| Gln 324 | - | expression tag |
| Gly 325 | - | expression tag |
| Gly 326 | - | expression tag |
| Ser 327 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 222317.8 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 4113.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 935.9 | |
| All* | Total formula weight | 227367.4 |
