7SE9
Crystal structure of human Fibrillarin in complex with compound 1 from single soak
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | rRNA 2'-O-methyltransferase fibrillarin | polymer | 242 | 26681.6 | 2 | UniProt (P22087) Pfam (PF01269) | Homo sapiens (Human) | 34 kDa nucleolar scleroderma antigen,Histone-glutamine methyltransferase,U6 snRNA 2'-O-methyltransferase fibrillarin |
| 2 | C, J (A, B) | (5S)-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one | non-polymer | 216.2 | 2 | Chemie (8W1) | |||
| 3 | D, E, F, G, H... (A, B) | FORMIC ACID | non-polymer | 46.0 | 8 | Chemie (FMT) | |||
| 4 | I, N (A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 5 | O, P (A, B) | water | water | 18.0 | 353 | Chemie (HOH) |
Sequence modifications
A, B: 83 - 321 (UniProt: P22087)
| PDB | External Database | Details |
|---|---|---|
| Ser 80 | - | expression tag |
| Asn 81 | - | expression tag |
| Ala 82 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 53363.2 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 956.8 | |
| All* | Total formula weight | 54320.0 |
